The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example

作者：Didier Raboisson, Ahmed Ferchiou, Beate Pinior, Thomas Gautier, Pierre Sans, Guillaume Lhermie · 发表于：Frontiers in Veterinary Science · 年份：2020 · DOI：10.3389/fvets.2020.00149 · 被引用次数：24 · 研究领域：Milk Quality and Mastitis in Dairy Cows、Animal Disease Management and Epidemiology、Genetic and phenotypic traits in livestock

The literature contains an extensive panel of studies focusing on the costs of animal diseases. Meta-analysis can be used to detect effects (i.e. change in clinical mastitis losses here) across studies and to identify factors that may influence those effects. This includes the external validity of the published study results with regard to the input parameters and the internal validity of the study. Mixed-effect meta-regressions were performed to estimate the mean clinical mastitis losses per case across the literature and to elucidate to what extent clinical mastitis losses are influenced by i) general factors, such as aetiology; ii) the types of losses that contribute to the total mastitis losses; and iii) prices. In total, 82 observations from nine studies were included in the meta-analysis to assess mean clinical mastitis losses per case. The multivariate meta-regression showed that aetiology significantly influenced the clinical mastitis loss per case. The mean loss was determined to be €224 per case for all published aetiologies. In detail, mean losses equalled €457 and €101 per case of clinical mastitis due to gram-negative and gram-positive bacteria, respectively, and €428 and €74 per case of clinical mastitis due to Escherichia coli and Staphylococcus aureus, respectively. Additionally, the mean loss obtained depended on whether diagnostic costs and reduced feed intake in cases of mastitis were included in the clinical mastitis loss calculation. The monetary values o...