Single‐Cell RNA Sequencing in Hematological Diseases

作者：Yue Zhu, Yao‐Hui Huang, Yun Tan, Weili Zhao, Qiang Tian · 发表于：PROTEOMICS · 年份：2020 · DOI：10.1002/pmic.201900228 · 被引用次数：35 · 研究领域：Single-cell and spatial transcriptomics、Cancer Genomics and Diagnostics、Acute Myeloid Leukemia Research

Hematological diseases, including leukemia, lymphoma, and multiple myeloma, are characterized by high heterogeneity with diverse cellular subpopulations. Single-cell RNA sequencing (scRNA-seq), a transformational technology, provides deep insights into cell-to-cell variation in tumor and microenvironment, allows high-resolution dissection of the pathogenic mechanisms of diseases, and affords potential clinical utilities. Recent developments in single-cell transcriptomics and associated technologies and their applications in hematological disorders for unraveling cellular subpopulations, disease pathogenesis, patient stratification, and therapeutic responses are summarized.