Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD)

作者：Zhongyan Wang, Chuanrui Ma, Yuna Shang, Lijun Yang, Jing Zhang, Cuihong Yang, Chunhua Ren, Jinjian Liu, Jinjian Liu, Guanwei Fan, Jianfeng Liu, Jianfeng Liu · 发表于：Chemical Communications · 年份：2020 · DOI：10.1039/d0cc00513d · 被引用次数：18 · 研究领域：Liver Disease Diagnosis and Treatment、Hepatitis C virus research、Endoplasmic Reticulum Stress and Disease

We have developed a co-assembled nanosystem based on fenofibrate and ketoprofen by tactfully utilizing their simultaneous benzophenone interaction, which greatly enhances the bioavailability of fenofibrate and plays a role in the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.