The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study

作者：Jing Liang, Yutong Jiang, Yefei Huang, Wei Song, Xiaomin Li, Yulan Huang, Jiayong Ou, Qiujing Wei, Jieruo Gu · 发表于：Lipids in Health and Disease · 年份：2020 · DOI：10.1186/s12944-020-1197-y · 被引用次数：85 · 研究领域：Gout, Hyperuricemia, Uric Acid、Diet, Metabolism, and Disease、Thyroid Disorders and Treatments

Abstract Background Dyslipidemia often concurs with hyperuricemia. Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia and the predictors of sUA (serum uric acid) levels. Methods A cross-sectional study was performed to collect demographic, clinical variables, comorbidities and laboratory testing in patients with gout and asymptomatic hyperuricemia. Group comparison was performed with Student’s t -test or Mann Whitney U test for continuous variables and chi-squared tests for categorical variables (Fisher’s exact test where appropriate) and to screen potential risk factors. Correlation of sUA levels with demographic and biochemical variables were performed by using correlation analysis. The variable with s p -value less than 0.20 during the group comparison or clinical relevance was introduced into the stepwise multiple regression model. Results Six hundred fifty-three patients with gout and 63 patients with asymptomatic hyperuricemia (> 420 μmol/L in male and > 360 μmol/L in female) were enrolled, including 553 (84.7%) males. The mean age was 47.8 ± 16.0 years old. Elevated total cholesterol (TC) was observed in 173 (26.5%) cases with gout. Increased triglycerides (TG) and low-density lipoprotein (LDL-C) levels were observed in 242 (37.1%) cases and 270 (41.3%) cases with gout, individually. In contrast, elevated TC, TG and LDL-C levels were observed in 10 (15.9%) cases, 30 (47.6%) cases and 22 (34.9%) cases with hyperuricemia, individually...