Predictors of outcome in early onset schizophrenia: a 10-year follow-up study

作者：Lingzi Xu, Yanqing Guo, Qingjiu Cao, Xue Li, Ting Mei, Zenghui Ma, Xinzhou Tang, Zhao-Zheng Ji, Liu Yang, Jing Liu · 发表于：BMC Psychiatry · 年份：2020 · DOI：10.1186/s12888-020-2484-x · 被引用次数：20 · 研究领域：Schizophrenia research and treatment、Mental Health and Psychiatry、Healthcare Decision-Making and Restraints

BACKGROUND: Younger age at onset is generally thought to be a predictor of poor outcome in Early Onset Schizophrenia (EOS), but there is a paucity of epidemiological data supporting this belief. This study aims to describe long-term outcomes and predictors of patient functioning in EOS, with a focus on the effect of age at onset. METHODS: We consecutively enrolled 118 EOS patients who were hospitalized in 2006. Mean age at baseline was 13.3 ± 2.3 years. Sixty-five subjects were successfully interviewed. Mean length of follow up was 10.4 ± 0.3 years. Baseline data were collected from inpatient medical records, while follow up was conducted primarily through telephone interviews of patient relatives. WHODAS 2.0 was used to measure global functioning at follow up. Outcomes included education, employment, marriage status, physical health, subsequent diagnoses and treatment, and patient functioning. Univariate and multivariate regression models were used to assess predictors of outcome, while propensity scores were used to adjust for confounding in analyzing the effect of age at onset on functional outcome. RESULTS: Of the 65 subjects where follow-up data were available, 3 were deceased at follow up. Five (8%) discontinued treatment. Diagnostic stability was 76%. Nearly a quarter (24%) were using clozapine at follow up. In male and female patients, 61 and 55% respectively were overweight, while 29 and 32% respectively were obese. Sixteen (26%) were economically self-sufficient, wh...