Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

作者：Wei‐jie Guan, Wenhua Liang, Yi Zhao, Hengrui Liang, Zisheng Chen, Yimin Li, Xiaoqing Liu, Ruchong Chen, Chunli Tang, Tao Wang, Chun‐Quan Ou, Li Li, Pingyan Chen, Ling Sang, Wei Wang, Jianfu Li, Caichen Li, Limin Ou, Bo Cheng, Shan Xiong, Zhengyi Ni, Jie Xiang, Yu Hu, Lei Liu, Hong Shan, Chunliang Lei, Yixiang Peng, Li Wei, Yong Liu, Yahua Hu, Peng Peng, Jianming Wang, Jiyang Liu, Zhong Chen, Gang Li, Zhijian Zheng, Shaoqin Qiu, Jie Luo, Chang-jiang Ye, Shaoyong Zhu, Linling Cheng, Feng Ye, Shiyue Li, Jin-ping Zheng, Nuofu Zhang, Nanshan Zhong, Jianxing He · 发表于：medRxiv · 年份：2020 · DOI：10.1101/2020.02.25.20027664 · 被引用次数：650 · 研究领域：COVID-19 Clinical Research Studies、Chronic Disease Management Strategies、COVID-19 and healthcare impacts

Abstract Objective To evaluate the spectrum of comorbidities and its impact on the clinical outcome in patients with coronavirus disease 2019 (COVID-19). Design Retrospective case studies Setting 575 hospitals in 31 province/autonomous regions/provincial municipalities across China Participants 1,590 laboratory-confirmed hospitalized patients. Data were collected from November 21 st , 2019 to January 31 st , 2020. Main outcomes and measures Epidemiological and clinical variables (in particular, comorbidities) were extracted from medical charts. The disease severity was categorized based on the American Thoracic Society guidelines for community-acquired pneumonia. The primary endpoint was the composite endpoints, which consisted of the admission to intensive care unit (ICU), or invasive ventilation, or death. The risk of reaching to the composite endpoints was compared among patients with COVID-19 according to the presence and number of comorbidities. Results Of the 1,590 cases, the mean age was 48.9 years. 686 patients (42.7%) were females. 647 (40.7%) patients were managed inside Hubei province, and 1,334 (83.9%) patients had a contact history of Wuhan city. Severe cases accounted for 16.0% of the study population. 131 (8.2%) patients reached to the composite endpoints. 399 (25.1%) reported having at least one comorbidity. 269 (16.9%), 59 (3.7%), 30 (1.9%), 130 (8.2%), 28 (1.8%), 24 (1.5%), 21 (1.3%), 18 (1.1%) and 3 (0.2%) patients reported having hypertension, cardiovascul...