The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression

作者：Leonardo Tozzi, Brooke R. Staveland, Bailey Holt-Gosselin, Megan Chesnut, Sarah Chang, David Choi, Melissa Shiner, Hua Wu, Garikoitz Lerma‐Usabiaga, Olaf Sporns, Deanna M. Barch, Ian H. Gotlib, Trevor Hastie, Adam B. Kerr, Russell A. Poldrack, Brian A. Wandell, Max Wintermark, Leanne M. Williams · 发表于：NeuroImage · 年份：2020 · DOI：10.1016/j.neuroimage.2020.116715 · 被引用次数：54 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Neural dynamics and brain function

Through the Human Connectome Project (HCP) our understanding of the functional connectome of the healthy brain has been dramatically accelerated. Given the pressing public health need, we must increase our understanding of how connectome dysfunctions give rise to disordered mental states. Mental disorders arising from high levels of negative emotion or from the loss of positive emotional experience affect over 400 million people globally. Such states of disordered emotion cut across multiple diagnostic categories of mood and anxiety disorders and are compounded by accompanying disruptions in cognitive function. Not surprisingly, these forms of psychopathology are the leading cause of disability worldwide. The Research Domain Criteria (RDoC) initiative spearheaded by NIMH offers a framework for characterizing the relations among connectome dysfunctions, anchored in neural circuits and phenotypic profiles of behavior and self-reported symptoms. Here, we report on our Connectomes Related to Human Disease protocol for integrating an RDoC framework with HCP protocols to characterize connectome dysfunctions in disordered emotional states, and present quality control data from a representative sample of participants. We focus on three RDoC domains and constructs most relevant to depression and anxiety: 1) loss and acute threat within the Negative Valence System (NVS) domain; 2) reward valuation and responsiveness within the Positive Valence System (PVS) domain; and 3) working memory...