Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

作者：Stephen A. Harrison, Vincent Wai‐Sun Wong, Takeshi Okanoue, Natalie Bzowej, Raj Vuppalanchi, Ziad Younes, Anita Kohli, Shiv Kumar Sarin, Stephen H. Caldwell, Naim Alkhouri, Mitchell L. Shiffman, Marianne Camargo, Georgia Li, Kathryn Kersey, Catherine Jia, Yanni Zhu, C. Stephen Djedjos, G. Mani Subramanian, Robert P. Myers, Nadege Gunn, Aasim Sheikh, Quentin M. Anstee, Manuel Romero‐Gómez, Michael Trauner, Zachary Goodman, Eric Lawitz, Zobair M. Younossi, Adrián Gadano, Marcelo Martins, Peter Angus, John Bate, Mark Danta, Jacob George, Alexander Hodge, Nickolas Kontorinis, S.A. Roberts, Santosh Sanagapalli, Richard Skoien, Alexander Thompson, Amany Zekry, Rudolf Stauber, Michael Trauner, Christophe Moreno, Hendrik Reynaert, Len Verbeke, Mário Reis Álvares‐da‐Silva, Edison Roberto Parise, Cláudia P. Oliveira, Roberta Chaves Araújo, Ana de Lourdes Candolo Martinelli, Meredith A. Borman, Natasha Chandok, Magdy Elkhashab, Hughie F. Fraser, Kelly Kaita, Mang Ma, Paul Marotta, Alnoor Ramji, Edward Tam, Eric M. Yoshida, Mark G. Swain, Giada Sebastiani, Denis Petrunia, Armand Abergel, Rodolphe Anty, Marc Bourlière, Jérôme Boursier, Christophe Bureau, Laurent Castéra, François Habersetzer, Christophe Hézode, V. de Lédinghen, Vincent Leroy, V. Loustaud‐Ratti, Philippe Mathurin, Stanislas Pol, Fabien Zoulim, Holger Hinrichsen, Patrick Ingiliz, Frank Lammert, Michael Manns, Jörn M. Schattenberg, Ingolf Schiefke, Christian Trautwein, Stefan Zeuzem, Aric J. Hui, K Li, Vincent Wai‐Sun Wong, Subrat Kumar Acharya, Abhijit Chowdhury, Ajay Duseja, Dharmesh Kapoor, Shrikant Mukewar, Shiv Kumar Sarin, Samir Shah, S. Shalimar, Ajit Sood, BV Tantry, Ziv Ben‐Ari, Helena Katchman, Rifaat Safadi, Ella Veitsman, Eli Zuckerman, Maurizia Rossana Brunetto, Pietro Lampertico, Alessandra Mangia, Takemi Akahane, Norio Akuta, Norio Akuta, Yuichiro Eguchi, Shigetoshi Fujiyama, Takuya Genda, Yoichi Hiasa, Akio Ido, Fusao Ikeda, Tadashi Ikegami, Kento Imajo, Yoshito Itoh, Motoh Iwasa, Yoshiyasu Karino, Naoya Kato, Takumi Kawaguchi, Miwa Kawanaka, Masahiro Kido, Tomoo Kobayashi, Masayuki Kurosaki, Yasushi Matsuzaki, Eiji Mita, Eishiro Mizukoshi, Takashi Nakahara, Hideyuki Nomura, Kazuo Notsumata, Takeshi Okanoue, Satoshi Saito, Hiroshi Sakugawa, Yoshiyuki Suzuki, Koichi Takaguchi, Akinobu Takaki, Tomoyuki Takashima, Saiyu Tanaka, Keiji Tsuji, Yoshiyuki Ueno, Takeji Umemura, Hirofumi Uto, Nobuyuki Yamashita, Mikio Yanase, Hiroshi Yatsuhashi, Masashi Yoneda, Wah‐Kheong Chan, Soek Siam Tan, Laura Garza, Alma Ladron de Guevara Cetina, Rocio Guadalupe Vargas Angeles, Francisca Martinez Silva, Karel van Erpecum, David Orr, Maciej Jabłkowski, Jerzy Jaroszewicz, José Manuel Ramos, Taufique Ahmed, Tiing Leong Ang, Yock Young Dan, Boon Bee George Goh, Kalaiyarasi Kaliyaperumal, Cherng Hann Yip, Soon Koo Baik, Byoung Kuk Jang, Dae Won Jun, Won–Ho Kim, Hyung Joon Kim, Ji Hoon Kim, Kwan Sik Lee, Chun Kyon Lee, Young-Suk Lim, Jun Yong Park, Won Young Tak, Salvador Augustín, Salvador Benlloch Perez, Juan Caballería, José Luís, Calleja Panero, José A. Rodríguez, Javier Crespo Garcia, Javier García‐Samaniego, Pere Ginés Gibert, M. Prieto, Manuel Romero‐Gómez, Juan Turnés, Jean‐François Dufour, Alberto Moriggia, I-Shyan Sheen, Jia‐Horng Kao, Pin‐Nan Cheng, Jee‐Fu Huang, Sheng‐Shun Yang, Wei‐Wen Su, Chi-Yi Chen, Rong‐Nan Chien, Gin‐Ho Lo, Chi-Jen Chu, Horng-Yuan Wang, Jui-Ting Hu, Yi‐Wen Huang, Kosh Agarwal, Michael Allison, Quentin M. Anstee, Andrew D. Austin, Andrew Fowell, Chin Lye Ch’ng, Pinelopi Manousou, Philip N. Newsome, Stephen Ryder, Arun Shankar, Manal F. Abdelmalek, Gary A. Abrams, Humberto Aguilar, Imtiaz Alam, Laura Alba, Naim Alkhouri, Alina M. Allen, Bashar Aqel, Luis A. Balart, A. Sidney Barritt, Jaideep Behari, Michael Bennett, David I. Bernstein, Bal Raj Bhandari, Maurizio Bonacini, Brian B. Borg, Kimberly Brown, Natalie Bzowej, Stephen H. Caldwell, Tawfik N. Chami, Allan Coates, Adolfo Cueli, Mitchell Davis, Andrew S. deLemos, Archita P. Desai, Winston Dunn, Nelson Henrique da Silva Ferreira, Michael Fine, Roberto Firpi-Morell, Curtis Freedland, B. Freilich, Michael Fuchs, Michael Galambos, Juan F. Gallegos‐Orozco, Greg Galler, Maged P. Ghali, Reem Ghalib, Satinder Gill, Marcum Gillis, Richard Gilroy, S. Gordon, Nadege Gunn, Dina Halegoua‐De Marzio, Mohamed A. Hassan, Tarek Hassanein, Robert Herring, John D. Hong, Jonathan Huang, Heidi Kabler, Zeid Kayali, W Knapple, Geetha Kolli, Kris V. Kowdley, Richard A. Krause, Eric Lawitz, Steven D. Lidofsky, Joseph K. Lim, Donald Lipkis, Rohit Loomba, Amar Mahgoub, Miguel Malespin, Richard Manch, Steven Mannis, Paul Manos, Thomas J. McDonald, Mark McKenzie, Edward Mena, Raphael B. Merriman, Martin Moehlen, Richard Murdoch Montgomery, Robert L. Murphy, Yamini Natarajan, Guy Neff, Mazen Noureddin, Grisell Ortiz‐Lasanta, Mangesh Pagadala, Keyur Patel, Heather Patton, Adam Peyton, Neville R. Pimstone, John Poulos, David Pound, Nikolaos Pyrsopoulos, Nila Rafiq, Natarajan Ravendhran, Ravi Ravinuthala, K. Rajendar Reddy, Robert Reindollar, Justin Reynolds, Mary E. Rinella, Syed Rizvi, Don C. Rockey, Federico Rodríguez-Pérez, Peter Ruane, Raymond A. Rubin, Michael Ryan, Kia Saeian, Arun J. Sanyal, Souvik Sarkar, Andrew Scanga, Eugene R. Schiff, W Schmidt, Jeffrey Schneider, Thomas Sepe, Dhiren Shah, Obaid S. Shaikh, Uday Shankar, Aasim Sheikh, Muhammad Y. Sheikh, Kenneth E. Sherman, Mitchell L. Shiffman, Asma Siddique, Matthew Ryan Smith, Rosa Suarez, Andrew H. Talal, Helen S. Te, Bezawit Tekola, Brent Tetri, Paul J. Thuluvath, Doris H. Toro, Dawn M. Torres, Huy N. Trinh, James F. Trotter, Angel Vento, John M. Vierling, Raj Vuppalanchi, Michael F. Waters, Ilan Weisberg, Amanda Wieland, A. B. Williams, Ziad Younes, Leon A. Adams, Peter Angus, John Bate, Mark Danta, Jacob George, Damian Harding, Alex Hodge, Nick Kontorinis, S.A. Roberts, Richard Skoien, Simone I. Strasser, Alex J. Thompson, Amany Zekry, Rudolf Stauber, Michael Trauner, Yves Horsmans, Christophe Moreno, Hendrik Reynaert, Christophe Van Steenkiste, Len Verbeke, Robert J. Bailey, Meredith A. Borman, Natasha Chandok, Magdy Elkhashab, Hughie F. Fraser, Jeanne‐Marie Giard, Kelly Kaita, Paul Marotta, Aldo J. Montaño‐Loza, Keyur Patel, Denis Petrunia, Marco Puglia, Giada Sebastiani, Edward Tam, Keith Tsoi, Eric M. Yoshida, Armand Abergel, Rodolphe Anty, Marc Bourlière, Jérôme Boursier, Christophe Bureau, Laurent Castéra, François Habersetzer, Christophe Hézode, Dominique Larrey, Vincent Leroy, V. Loustaud‐Ratti, Philippe Mathurin, Éric Nguyen-Khac, Stanislas Pol, Vlad Ratziu, Fabien Zoulim, Jörn M. Schattenberg, U. Spengler, Christian Trautwein, Johannes Wiegand, Stefan Zeuzem, Aric J. Hui, Vincent Wai‐Sun Wong, Subrat Kumar Acharya, Abhijit Chowdhury, Ajay Duseja, Dharmesh Kapoor, Shrikant Mukewar, Shiv Kumar Sarin, Samir Shah, S. Shalimar, Ajit Sood, Vishwanath Tantry, Ziv Ben‐Ari, Marius Braun, Rawi Hazzan, Helena Katchman, Yoav Lurie, Rifaat Safadi, Ella Veitsman, Eli Zuckerman, Massimo Colombo, Pietro Lampertico, Alessandra Mangia, Takemi Akahane, Norio Akuta, Yuichiro Eguchi, Hideki Fujii, Shigetoshi Fujiyama, Takuya Genda, Etsuko Hashimoto, Yoichi Hiasa, Fusao Ikeda, Kento Imajo, Yoshito Itoh, Motoh Iwasa, Yoshiyasu Karino, Masaki Kato, Takumi Kawaguchi, Miwa Kawanaka, Masahiro Kido, Eishiro Mizukoshi, Kazuo Notsumata, Koji Ogawa, Takeshi Okanoue, Satoshi Saito, Yoshiyuki Suzuki, Tetsuo Takehara, Saiyu Tanaka, Katsutoshi Tokushige, Keiji Tsuji, Yoshiyuki Ueno, Takeji Umemura, Hirofumi Uto, Hiroshi Yatsuhashi, Masashi Yoneda, Laura Garza, Alma Laura Ladrón De Guevara, David Orr, Michael Schultz, Maciej Jabłkowski, Ewa Janczewska, Jerzy Jaroszewicz, Grisell Ortiz‐Lasanta, Federico Rodríguez-Pérez, Doris H. Toro, Byoung Kuk Jang, Sook‐Hyang Jeong, Ji Hoon Kim, Won–Ho Kim, Yoon Jun Kim, Chun Kyon Lee, Jin‐Woo Lee, Kwan Sik Lee, Young-Suk Lim, Won Young Tak, Tiing Leong Ang, George Goh Boon Bee, Kalaiyarasi Kaliyaperumal, Salvador Augustín, Salvador Benlloch, Juan Caballería, José Luís Calleja, José A. Rodríguez, Javier Crespo, M. Diago, Conrado Fernández‐Rodríguez, Javier García‐Samaniego, Pere Ginès, Manuel Romero‐Gómez, Juan Turnés, Jean‐François Dufour, Alberto Moriggia, Pin‐Nan Cheng, Jee‐Fu Huang, Jia‐Horng Kao, I-Shyan Sheen, Kosh Agarwal, William Alazawi, Chinlye Ch’Ng, Daniel Forton, Andrew Fowell, Pinelopi Manousou, Matthew Priest, Stephen Ryder, David Sheridan, Manal F. Abdelmalek, Gary A. Abrams, Humberto Aguilar, Imtiaz Alam, Laura Alba, Alina M. Allen, Victor Ankoma‐Sey, Bashar Aqel, Maya Balakrishnan, Luis A. Balart, Kiran Bambha, A. Sidney Barritt, Jaideep Behari, Michael Bennett, David I. Bernstein, Bal Raj Bhandari, Maurizio Bonacini, Brian B. Borg, Danielle Brandman, Kimberly Brown, Natalie Bzowej, Stephen H. Caldwell, Tawfik N. Chami, Charissa Chang, Allan Coates, Kathleen E. Corey, Adolfo Cueli, Mitchell Davis, Andrew S. deLemos, Winston Dunn, Michael Feldman, Nelson Henrique da Silva Ferreira, Roberto Firpi-Morell, B. Freilich, Michael Fuchs, Michael Galambos, Juan F. Gallegos‐Orozco, Greg Galler, Reem Ghalib, Pierre Gholam, Marcum Gillis, Richard Gilroy, John S. Goff, Nadege Gunn, Dina Halegoua‐De Marzio, Stephen A. Harrison, Tarek Hassanein, Paul Hellstern, Robert Herring, Jonathan Huang, Rajalakshmi Iyer, Antoine Jakiche, Zeid Kayali, Anita Kohli, Kris V. Kowdley, Richard A. Krause, Karen Krok, Marcelo Kugelmas, Sonal Kumar, Michelle Lai, Eric Lawitz, Steven D. Lidofsky, Rohit Loomba, Mitchell Mahʼmoud, Richard Manch, Steven Mannis, Parvez Mantry, Luis Marsano, Mark McKenzie, Edward Mena, Raphael B. Merriman, Richard Murdoch Montgomery, Robert L. Murphy, Yamini Natarajan, Guy Neff, Tuan Nguyen, Mazen Noureddin, James Park, Heather Patton, Neville R. Pimstone, Paul J. Pockros, John Poulos, David Pound, Nikolaos Pyrsopoulos, Nila Rafiq, Natarajan Ravendhran, Ravi Ravinuthala, K. Rajender Reddy, Robert Reindollar, Justin Reynolds, Mary E. Rinella, Don C. Rockey, Miguel Rodriguez, Peter Ruane, Raymond A. Rubin, Michael Ryan, Arun J. Sanyal, Souvik Sarkar, H Sarles, Sanjaya K. Satapathy, Andrew Scanga, Eugene R. Schiff, Shahriar Sedghi, Thomas Sepe, Dhiren Shah, Nikunj Shah, Uday Shankar, Aasim Sheikh, Muhammad Y. Sheikh, Kenneth E. Sherman, Mitchell L. Shiffman, Mitchell L. Shiffman, Asma Siddique, Samuel H. Sigal, Matthew Ryan Smith, Carmen Stanca, Michael Steinbook, Gyöngyi Szabó, Andrew H. Talal, Helen S. Te, Norah A. Terrault, Brent Tetri, Paul J. Thuluvath, Myron J. Tong, Dawn M. Torres, James F. Trotter, David G. Victor, John M. Vierling, Raj Vuppalanchi, Ilan Weisberg, Amanda Wieland, A. B. Williams, Ziad Younes, Xaralambos Zervos · 发表于：Journal of Hepatology · 年份：2020 · DOI：10.1016/j.jhep.2020.02.027 · 被引用次数：484 · 研究领域：Liver Disease Diagnosis and Treatment、Liver physiology and pathology、Liver Diseases and Immunity