Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

作者：Stephen A. Harrison, Vincent Wai‐Sun Wong, Takeshi Okanoue, Natalie H. Bzowej, Raj Vuppalanchi, Ziad H Younes, Anita A. Kohli, Shiv Kumar Sarin, Stephen Hugh Caldwell, Naim Alkhouri, Mitchell L. Shiffman, Marianne Camargo, Georgia Li, Kathryn Kersey, Catherine Jia, Yanni Zhu, C. Stephen Djedjos, G. Mani Subramanian, Robert P. Myers, Nadege Gunn, Aasim M. Sheikh, Quentin Mark Anstee, Manuel Romero‐Gómez, Michael A Trauner, Zachary D Goodman, Eric Lawitz, Zobair M. Younossi, Adrian Carlos Gadano, Marcelo Martins, Peter Angus, John P. Bate, Mark Danta, Jacob George, Alexander D. Hodge, Nickolas Kontorinis, Stuart Ashley Roberts, Santosh Sanagapalli, Richard Skoien, Alexander Thompson, Amany Zekry, Rudolf E Stauber, Michael A Trauner, Christophe Moreno, Hendrik Reynaert, Len Verbeke, Mário Reis Álvares‐da‐Silva, Edison Roberto Parise, Claudia Pinto Marques Souza de Oliveira, Roberta Chaves Araújo, Ana de Lourdes Candolo Martinelli, Meredith A. Borman, Natasha Chandok, Magdy Elkhashab, Hughie F. Fraser, Kelly Kaita, Mang M. Ma, Paul Marotta, Alnoor S. Ramji, Edward Tam, Eric M. Yoshida, Mark G. Swain, Giada Sebastiani, Denis M. Petrunia, Armand Abergel, Rodolphe Anty, Marc Bourlière, Jérôme Boursier, Christophe Bureau, Laurent Castéra, François Habersetzer, Christophe Hézode, V. de Lédinghen, Vincent Leroy, Véronique Loustaud-Ratti, Philippe Mathurin, Stanislas Pol, Fabien Zoulim, Holger M. Hinrichsen, Patrick Ingiliz, Frank Lammert, Michael Manns, Jörn Markus Schattenberg, Ingolf Schiefke, Christian Trautwein, Stefan Zeuzem, Aric Josun Hui, K Li, Vincent Wai‐Sun Wong, Subrat Kumar Acharya, Abhijit Chowdhury, Ajay Kumar. Duseja, Dharmesh Kapoor, Shrikant V Mukewar, Shiv Kumar Sarin, Samir Shah, S. Shalimar, Ajit Sood, BV Tantry, Ziv Ben‐Ari, Helena Katchman, Rifaat Safadi, Ella Veitsman, Eli Zuckerman, Maurizia Rossana Brunetto, Pietro Lampertico, Alessandra Mangia, Takemi Akahane, Norio Akuta, Norio Akuta, Yuichiro Eguchi, Shigetoshi Fujiyama, Takuya Genda, Yoichi Hiasa, Akio Ido, Fusao Ikeda, Tadashi Ikegami, Kento Imajo, Yoshito Itoh, Motoh Iwasa, Yoshiyasu Karino, Naoya Kato, Takumi Kawaguchi, Miwa Kawanaka, Masahiro Kido, Tomoo Kobayashi, Masayuki Kurosaki, Yasushi Matsuzaki, Eiji Mita, Eishiro Mizukoshi, Takashi Nakahara, Hideyuki Nomura, Kazuo Notsumata, Takeshi Okanoue, Satoshi Saito, Hiroshi Sakugawa, Yoshiyuki Suzuki, Koichi Takaguchi, Akinobu Takaki, Tomoyuki Takashima, Saiyu Tanaka, Keiji Tsuji, Yoshiyuki Ueno, Takeji Umemura, Hirofumi Uto, Nobuyuki Yamashita, Mikio Yanase, Hiroshi Yatsuhashi, Masashi Yoneda, Wah‐Kheong Chan, Soek Siam Tan, Laura Garza, Alma Ladron de Guevara Cetina, Rocio Guadalupe Vargas Angeles, Francisca Martinez Silva, Karel van Erpecum, David W. Orr, Maciej Jabłkowski, Jerzy Jaroszewicz, José Manuel Ramos, Taufique Ahmed, Tiing Leong Ang, Yock Young Dan, Boon Bee George Goh, Kalaiyarasi Kaliyaperumal, Cherng Hann Yip, Soon Koo Baik, Byoung Kuk Jang, Dae Won Jun, Won–Ho Kim, Hyung Joon Kim, Ji Hoon Kim, Kwan Sik Lee, Chun Kyon Lee, Young-Suk Lim, Jun Yong Park, Won Young Tak, Salvador Augustín, Salvador Benlloch Perez, Juan Caballería, José Ángel Hernández Luis, Calleja Panero, José Antonio Rodrı́guez, Javier Crespo Garcia, Javier García‐Samaniego, Pere Ginés Gibert, M. Prieto, Manuel Romero‐Gómez, Juan Turnés, Jean‐François Dufour, Alberto Moriggia, I-Shyan Sheen, Jia‐Horng Kao, Pin‐Nan Cheng, Jee‐Fu Huang, Sheng‐Shun Yang, Wei‐Wen Su, Chi-Yi Chen, Rong‐Nan Chien, Gin‐Ho Lo, Chi-Jen Chu, Horng-Yuan Wang, Jui-Ting Hu, Yi‐Wen Huang, Kosh Agarwal, Michael E. Allison, Quentin Mark Anstee, Andrew D. Austin, Andrew J. Fowell, Chin Lye Ch’ng, Pinelopi Manousou, Philip Noel Newsome, Stephen Ryder, Arun Shankar, Manal F. Abdelmalek, Gary A. Abrams, Humberto I. Aguilar, Imtiaz Alam, Laura M. Alba, Naim Alkhouri, Alina M. Allen, Bashar A. Aqel, Luis A. Balart, Alfred Sidney Barritt, Jaideep Behari, MICHAEL R. BENNETT, David I. Bernstein, Bal Raj Bhandari, Maurizio Bonacini, Brian B. Borg, Kimberly Brown, Natalie H. Bzowej, Stephen Hugh Caldwell, Tawfik N. Chami, Allan G. Coates, Adolfo Cueli, Mitchell N. Davis, Andrew S. deLemos, Archita P. Desai, Winston Dunn, Nelson Henrique da Silva Ferreira, Michael Fine, Roberto J. Firpi-Morell, Curtis Freedland, Bradley L. Freilich, Michael A. Fuchs, Michael R. Galambos, Juan Fernando Gallegos-Orozco, Greg W. Galler, Maged Peter Ghali, Reem H. Ghalib, Satinder Singh Gill, Marcum G. Gillis, Richard K. Gilroy, S. Gordon, Nadege Gunn, Dina Halegoua‐De Marzio, Mohamed Ahmed Salih Hassan, Tarek Hassanein, Robert Herring, John D. Hong, Jonathan H. Huang, Heidi Kabler, Zeid Kayali, W Knapple, Geetha Kolli, Kris V. Kowdley, Richard A. Krause, Eric Lawitz, Steven D. Lidofsky, Joseph K. Lim, Donald Lipkis, Rohit Seth Loomba, Amar Mahgoub, Miguel H. Malespin, Richard A. Manch, Steven Mannis, Paul Manos, Thomas J. McDonald, Mark D. McKenzie, Edward Mena, Raphael B. Merriman, Martin Moehlen, Richard Murdoch Montgomery, Robert L. Murphy, Yamini Natarajan, Guy W. Neff, Mazen Noureddin, Grisell Ortiz‐Lasanta, Mangesh R. Pagadala, Keyur Patel, Heather M. Patton, Adam Peyton, Neville R. Pimstone, John Poulos, David Pound, Nikolaos Pyrsopoulos, Nila Rafiq, Natarajan Ravendhran, Ravi Ravinuthala, K. Rajendar Reddy, Robert Reindollar, Justin A. Reynolds, Mary Eugenia Rinella, Syed Zaki Husain Rizvi, Don C. Rockey, Federico Rodríguez-Pérez, Peter Jerome Ruane, Raymond A. Rubin, Michael Ryan, Kia Saeian, Arun Jayant Sanyal, Souvik Sarkar, Andrew E. Scanga, Eugene R. Schiff, Warren Schmidt, Jeffrey Gary Schneider, Thomas E. Sepe, Dhiren A. Shah, Obaid Shakil Shaikh, Uday Shankar, Aasim M. Sheikh, Muhammad Y. Sheikh, Kenneth E. Sherman, Mitchell L. Shiffman, Asma Siddique, Matthew Ryan Smith, Rosa Suarez, Andrew H. Talal, Helen S. Te, Bezawit D. Tekola, Brent Tetri, Paul Joseph Thuluvath, Doris H. Toro, Dawn McDowell Torres, Huy Ngoc Trinh, James F. Trotter, Angel Vento, John Moore Vierling, Raj Vuppalanchi, Michael F. Waters, Ilan S. Weisberg, Amanda C. Wieland, A. B. Williams, Ziad H Younes, Leon A. Adams, Peter Angus, John P. Bate, Mark Danta, Jacob George, Damian Harding, Alex Hodge, Nick Kontorinis, Stuart Ashley Roberts, Richard Skoien, Simone Irene Strasser, Alex J. Thompson, Amany Zekry, Rudolf E Stauber, Michael A Trauner, Yves Horsmans, Christophe Moreno, Hendrik Reynaert, Christophe Van Steenkiste, Len Verbeke, Robert James Bailey, Meredith A. Borman, Natasha Chandok, Magdy Elkhashab, Hughie F. Fraser, Jeanne‐Marie Giard, Kelly Kaita, Paul Marotta, Aldo J. Montaño‐Loza, Keyur Patel, Denis M. Petrunia, Marco Puglia, Giada Sebastiani, Edward Tam, Keith Tsoi, Eric M. Yoshida, Armand Abergel, Rodolphe Anty, Marc Bourlière, Jérôme Boursier, Christophe Bureau, Laurent Castéra, François Habersetzer, Christophe Hézode, Dominique G. Larrey, Vincent Leroy, Véronique Loustaud-Ratti, Philippe Mathurin, Éric Nguyen-Khac, Stanislas Pol, Vlad Ratziu, Fabien Zoulim, Jörn Markus Schattenberg, Ulrich Spengler, Christian Trautwein, Johannes Wiegand, Stefan Zeuzem, Aric Josun Hui, Vincent Wai‐Sun Wong, Subrat Kumar Acharya, Abhijit Chowdhury, Ajay Kumar. Duseja, Dharmesh Kapoor, Shrikant V Mukewar, Shiv Kumar Sarin, Samir Shah, S. Shalimar, Ajit Sood, Vishwanath Tantry, Ziv Ben‐Ari, Marius Braun, Rawi Hazzan, Helena Katchman, Yoav Lurie, Rifaat Safadi, Ella Veitsman, Eli Zuckerman, Massimo Colombo, Pietro Lampertico, Alessandra Mangia, Takemi Akahane, Norio Akuta, Yuichiro Eguchi, Hideki Fujii, Shigetoshi Fujiyama, Takuya Genda, Etsuko Hashimoto, Yoichi Hiasa, Fusao Ikeda, Kento Imajo, Yoshito Itoh, Motoh Iwasa, Yoshiyasu Karino, Masaki Kato, Takumi Kawaguchi, Miwa Kawanaka, Masahiro Kido, Eishiro Mizukoshi, Kazuo Notsumata, Koji Ogawa, Takeshi Okanoue, Satoshi Saito, Yoshiyuki Suzuki, Tetsuo Takehara, Saiyu Tanaka, Katsutoshi Tokushige, Keiji Tsuji, Yoshiyuki Ueno, Takeji Umemura, Hirofumi Uto, Hiroshi Yatsuhashi, Masashi Yoneda, Laura Garza, Alma Laura Ladrón De Guevara, David W. Orr, Michael Schultz, Maciej Jabłkowski, Ewa Janczewska, Jerzy Jaroszewicz, Grisell Ortiz‐Lasanta, Federico Rodríguez-Pérez, Doris H. Toro, Byoung Kuk Jang, Sook‐Hyang Jeong, Ji Hoon Kim, Won–Ho Kim, Yoon Jun Kim, Chun Kyon Lee, Jin‐Woo Lee, Kwan Sik Lee, Young-Suk Lim, Won Young Tak, Tiing Leong Ang, George Goh Boon Bee, Kalaiyarasi Kaliyaperumal, Salvador Augustín, Salvador Benlloch, Juan Caballería, José Luís Calleja, José Antonio Rodrı́guez, Javier Crespo, M. Diago, Conrado Fernández‐Rodríguez, Javier García‐Samaniego, Pere Ginès, Manuel Romero‐Gómez, Juan Turnés, Jean‐François Dufour, Alberto Moriggia, Pin‐Nan Cheng, Jee‐Fu Huang, Jia‐Horng Kao, I-Shyan Sheen, Kosh Agarwal, William Alazawi, Chinlye Ch’Ng, Daniel M. Forton, Andrew J. Fowell, Pinelopi Manousou, Matthew Priest, Stephen Ryder, David A. Sheridan, Manal F. Abdelmalek, Gary A. Abrams, Humberto I. Aguilar, Imtiaz Alam, Laura M. Alba, Alina M. Allen, Victor Ankoma‐Sey, Bashar A. Aqel, Maya Balakrishnan, Luis A. Balart, Kiran M. Bambha, Alfred Sidney Barritt, Jaideep Behari, MICHAEL R. BENNETT, David I. Bernstein, Bal Raj Bhandari, Maurizio Bonacini, Brian B. Borg, Danielle Brandman, Kimberly Brown, Natalie H. Bzowej, Stephen Hugh Caldwell, Tawfik N. Chami, Charissa Chang, Allan G. Coates, Kathleen E. Corey, Adolfo Cueli, Mitchell N. Davis, Andrew S. deLemos, Winston Dunn, Michael Feldman, Nelson Henrique da Silva Ferreira, Roberto J. Firpi-Morell, Bradley L. Freilich, Michael A. Fuchs, Michael R. Galambos, Juan Fernando Gallegos-Orozco, Greg W. Galler, Reem H. Ghalib, Pierre Gholam, Marcum G. Gillis, Richard K. Gilroy, John S. Goff, Nadege Gunn, Dina Halegoua‐De Marzio, Stephen A. Harrison, Tarek Hassanein, Paul A. Hellstern, Robert Herring, Jonathan H. Huang, Rajalakshmi V. Iyer, Antoine Jakiche, Zeid Kayali, Anita A. Kohli, Kris V. Kowdley, Richard A. Krause, Karen L. Krok, Marcelo Kugelmas, Sonal Rajesh Kumar, Michelle Lai, Eric Lawitz, Steven D. Lidofsky, Rohit Seth Loomba, Mitchell A. Mahʼmoud, Richard A. Manch, Steven Mannis, Parvez Mantry, Luis Marsano, Mark D. McKenzie, Edward Mena, Raphael B. Merriman, Richard Murdoch Montgomery, Robert L. Murphy, Yamini Natarajan, Guy W. Neff, Tuan Nguyen, Mazen Noureddin, James S Park, Heather M. Patton, Neville R. Pimstone, Paul J. Pockros, John Poulos, David Pound, Nikolaos Pyrsopoulos, Nila Rafiq, Natarajan Ravendhran, Ravi Ravinuthala, K. Rajender Reddy, Robert Reindollar, Justin A. Reynolds, Mary Eugenia Rinella, Don C. Rockey, Miguel Rodriguez, Peter Jerome Ruane, Raymond A. Rubin, Michael Ryan, Arun Jayant Sanyal, Souvik Sarkar, Harry E. Sarles, Sanjaya Kumar Satapathy, Andrew E. Scanga, Eugene R. Schiff, Shahriar Sedghi, Thomas E. Sepe, Dhiren A. Shah, Nikunj Shah, Uday Shankar, Aasim M. Sheikh, Muhammad Yasin Sheikh, Kenneth E. Sherman, Mitchell L. Shiffman, Mitchell L. Shiffman, Asma Siddique, Samuel Harold Sigal, Matthew Ryan Smith, Carmen M. Stanca, Michael Steinbook, Gyöngyi Szabó, Andrew H. Talal, Helen S. Te, Norah A. Terrault, Brent Tetri, Paul Joseph Thuluvath, Myron John Tong, Dawn McDowell Torres, James F. Trotter, David G. Victor, John Moore Vierling, Raj Vuppalanchi, Ilan S. Weisberg, Amanda C. Wieland, A. B. Williams, Ziad H Younes, Xaralambos Bobby Zervos · 发表于：Journal of Hepatology · 年份：2020 · DOI：10.1016/j.jhep.2020.02.027 · 被引用次数：494 · 研究领域：Liver Disease Diagnosis and Treatment、Liver physiology and pathology、Liver Diseases and Immunity