Development of oncolytic virotherapy: from genetic modification to combination therapy

作者：Qiaoshuai Lan, Shuai Xia, Qian Wang, Wei Xu, Haiyan Huang, Shibo Jiang, Lu Lu · 发表于：Frontiers of Medicine · 年份：2020 · DOI：10.1007/s11684-020-0750-4 · 被引用次数：70 · 研究领域：Virus-based gene therapy research、CAR-T cell therapy research、Viral Infectious Diseases and Gene Expression in Insects

Oncolytic virotherapy (OVT) is a novel form of immunotherapy using natural or genetically modified viruses to selectively replicate in and kill malignant cells. Many genetically modified oncolytic viruses (OVs) with enhanced tumor targeting, antitumor efficacy, and safety have been generated, and some of which have been assessed in clinical trials. Combining OVT with other immunotherapies can remarkably enhance the antitumor efficacy. In this work, we review the use of wild-type viruses in OVT and the strategies for OV genetic modification. We also review and discuss the combinations of OVT with other immunotherapies.