A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process

作者：Yongxi Liang, Mei‐Lin Tang, Zhipeng Huo, Chenchen Zhang, Xun Sun · 发表于：Molecules · 年份：2020 · DOI：10.3390/molecules25051138 · 被引用次数：6 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Chemical Synthesis and Reactions

An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.