The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders

作者：Sonia Missiroli, Ilaria Genovese, Mariasole Perrone, Bianca Vezzani, Veronica Angela Maria Vitto, Carlotta Giorgi · 发表于：Journal of Clinical Medicine · 年份：2020 · DOI：10.3390/jcm9030740 · 被引用次数：238 · 研究领域：Inflammasome and immune disorders、interferon and immune responses、Neuroinflammation and Neurodegeneration Mechanisms

The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflammatory signaling, identifying these organelles as a central platform for the control of innate immunity and the inflammatory response. Thus, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Strategies aimed at reestablishing normal mitochondrial physiology could represent both preventive and therapeutic interventions for various pathologies related to exacerbated inflammation. Here, we explore the current understanding of the intricate interplay between mitochondria and the innate immune response in specific inflammatory diseases, such as neurological disorders and cancer.