Association Between Breast and Thyroid Lesions: A Cross-Sectional Study Based on Ultrasonography Screening in China

作者：Hao Li, Ze Wang, Jia-shuo Liu, Bao-shan Zou, Hao Chen, Zhou Xu, Hong Li, Shen Tian, Yanling Shi, Shu Li, Kainan Wu, Ran Liang, Lingquan Kong · 发表于：Thyroid · 年份：2020 · DOI：10.1089/thy.2019.0184 · 被引用次数：14 · 研究领域：Cancer Risks and Factors、Thyroid Cancer Diagnosis and Treatment、Global Cancer Incidence and Screening

Introduction: Prior research has shown an association between breast and thyroid cancers, although their relationship is unclear. In China, asymptomatic women undergoing regular health checkups usually undergo breast and thyroid ultrasonography screening. The present cross-sectional ultrasound-based study estimated the prevalence of breast masses (BM) and thyroid nodules (TN) and their relationship among a population-based cohort of Chinese women. Methods: This study included 34,184 consecutive asymptomatic Chinese women who underwent both breast and thyroid ultrasound evaluation during one health care examination. Detected lesions were assigned into categories of different malignant risks according to the Breast and Thyroid Imaging Reporting and Data System (BI-/TI-RADS). Binomial logistic regression was used to determine the association between occurrence of BM and TN, and multinomial logistic regression was used to analyze the correlation of BM and TN in different BI-/TI-RADS categories. Associations between BM and TN, as well as anthropometric and biochemical markers, were also explored. Results: Of those enrolled, 6371 (18.6%) had BM, 12,153 (35.6%) had TN, and 2279 (6.7%) had both. After adjusting for age, body mass index (BMI), and height, females with TN had a higher risk of BM (odds ratio [OR] = 1.151, 95% confidence interval [CI 1.081–1.225], p < 0.0001) than those with normal thyroids, and females with BM had a higher risk of TN (OR = 1.165 [CI 1.096–1.238], p &...