Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases

作者：Seonwook Kim, Venkateswaran Subramanian, Ahmed Abdel‐Latif, Sangderk Lee · 发表于：Metabolic Syndrome and Related Disorders · 年份：2020 · DOI：10.1089/met.2019.0120 · 被引用次数：46 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Lipid metabolism and disorders、Angiogenesis and VEGF in Cancer

Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.