Diastereoselective Synthesis of Cycloheptannelated Indoles via Lewis-Acid-Catalyzed (4 + 3)-Cyclization of Donor–Acceptor Cyclopropanes

作者：Bao Qiong Li, Zong‐Wang Qiu, Ai‐Jun Ma, Jin‐Bao Peng, Na Feng, Ji‐Yuan Du, Han‐Peng Pan, Xiang‐Zhi Zhang, Xue-Tao Xu · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c00248 · 被引用次数：46 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic Alkyne Reactions、Catalytic C–H Functionalization Methods

An efficient and straightforward Lewis-acid-mediated stereoselective (4 + 3)-cyclization of indole-substituted alkylidene malonates and donor-acceptor cyclopropanes has been developed involving the Friedel-Crafts/Michael addition cyclization cascade. This reaction provides a mild and effective method for the construction of synthetically and structurally interesting functionalized cycloheptannelated indoles.