Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

作者：Peng Jin, Lily Yeh Jan, Yuh Nung Jan · 发表于：Annual Review of Neuroscience · 年份：2020 · DOI：10.1146/annurev-neuro-070918-050509 · 被引用次数：291 · 研究领域：Erythrocyte Function and Pathophysiology、Ion channel regulation and function、Connexins and lens biology

Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit their biological roles. How mechanosensitive channels work, especially in animals, has been extensively studied in the past decade. Here we review key findings in the functional and structural characterizations of these channels and highlight the structural features relevant to the mechanotransduction mechanism of each specific channel.