Obstructive sleep apnea syndrome and causal relationship with female breast cancer: a mendelian randomization study

作者：Xiaoling Gao, Zhi-Mei Jia, Fangfang Zhao, Dong‐Dong An, Bei Wang, Erjing Cheng, Yan Chen, Jiannan Gong, Dai Liu, Ya‐Qiong Huang, Jiaojiao Yang, Shujuan Wang · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.102725 · 被引用次数：33 · 研究领域：Obstructive Sleep Apnea Research、Head and Neck Cancer Studies、Tracheal and airway disorders

). Replication in the Asian population of the BCAC study also supported our results (IVW OR, 1.33 for BC risk per log-odds increment in OSAS risk, 95% CI = 1.13-1.56; P = 0.0006). Sensitivity analyses confirmed the robustness of our findings. We provide novel evidence that genetically determined higher risk of OSAS has a causal effect on higher risk of BC. Further studies focused on the mechanisms of the relationship between OSAS and breast carcinogenesis are needed.