Prospective Associations of Accelerometer-Measured Physical Activity and Sedentary Time With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality

作者：Paddy C. Dempsey, Tessa Strain, Kay‐Tee Khaw, Nicholas J. Wareham, Søren Brage, Katrien Wijndaele · 发表于：Circulation · 年份：2020 · DOI：10.1161/circulationaha.119.043030 · 被引用次数：105 · 研究领域：Physical Activity and Health、Obesity, Physical Activity, Diet、Cardiovascular and exercise physiology

◼ lifestyle ◼ mortality ◼ neoplasms ◼ public health ◼ sedentary behavior B oth insufficient moderate-to-vigorous intensity physical activity (MVPA) and high volumes of sedentary time (ST) have been associated with increased risk of all-cause mortality, cardiovascular disease (CVD), and some cancers. 1 However, epidemiological evidence has relied mostly on self-reported physical activity (PA) and ST measures, which are prone to reporting bias and measurement error.Cohort studies incorporating more objective assessments are emerging, [2][3][4] but few investigate relationships of accelerometer-measured PA and ST with clinical end points, particularly incident CVD, and include both men and women.5 In addition, the relevance of light intensity PA (LIPA) in this context, which is an important contributor to total PA and may be a more feasible behavioral target for middle to older aged adults, remains unclear.Here, we examine the prospective associations of accelerometer-measured PA and ST with incident CVD (primary outcome), incident cancer, and all-cause mortality.Participants were from the European Prospective Investigation Into Cancer and Nutrition-Norfolk study, a population-based cohort of 25 639 adults 40 to 79 years of age residing in Norfolk, UK.Between 2004 and 2016, 7820 participants attending in-clinic assessments wore an accelerometer (ActiGraph GT1M/GT3X+) on their right hip for 7 days during waking hours.We excluded those with <4 days of sufficient wear time (>10 hou...