Upconversion nanotubes with tunable fluorescence properties based on Gd 2 O 2 S:Ln 3+ (Ln 3+  = Yb 3+ , Er 3+ ) and derivatives for photodynamic therapy

作者：Mei Yang, Qingyuan Gui, Jinlei Ma, Lei Qi, Bijun Bao, Yida Huang · 发表于：IET Nanobiotechnology · 年份：2020 · DOI：10.1049/iet-nbt.2019.0376 · 被引用次数：5 · 研究领域：Luminescence Properties of Advanced Materials、Nanoplatforms for cancer theranostics、Perovskite Materials and Applications

In this study, Gd 2 O 2 S:Ln 3+ (Ln 3+ = Yb 3+ , Er 3+ ) upconversion nanotubes (UCNTs) were synthesised by using Gd(OH) 3 :Ln 3+ (Ln 3+ = Yb 3+ , Er 3+ ) nanotubes as the template. The luminescent and biological properties of Gd 2 O 2 S:Ln 3+ (Ln 3+ = Yb 3+ , Er 3+ ) UCNTs, along with photodynamic therapy (PDT) applications of the Gd 2 O 2 S:8%Yb 3+ , 2%Er 3+ UCNT–Ce6 (chlorin e6) nanocomposites, were systematically studied. The resultant UCNTs showed excellent biocompatibility with human retinal pigment cells (ARPE‐19) even after a prolonged incubation time of 72 h, and could be used as luminescent probes. Microscopic imaging revealed that the UCNTs existed mainly in cytoplasm. PDT studies on the Gd 2 O 2 S:8%Yb 3+ , 2%Er 3+ UCNT–Ce6 nanocomposites indicate that the growth of the tumour (cell) could be inhibited dramatically when it was injected (incubated) with Gd 2 O 2 S:8%Yb 3+ , 2%Er 3+ UCNT–Ce6 nanocomposites under the irradiation of 980 nm laser.