International standards for fetal brain structures based on serial ultrasound measurements from Fetal Growth Longitudinal Study of INTERGROWTH ‐21 st Project

作者：R. Napolitano, M. Molloholli, V. Donadono, Eric O. Ohuma, Sikolia Wanyonyi, B. Kemp, Mohammad Yaqub, Stephen Ash, Fernando C. Barros, Mário Henrique Burlacchini de Carvalho, Yasmin A. Jaffer, J. Alison Noble, M. Oberto, Manorama Purwar, Ran Pang, Leila Cheikh Ismail, Ann Lambert, Michael G. Gravett, Laurent Salomon, Zulfiqar A Bhutta, Sidney H. Kennedy, José Villar, Aris T. Papageorghiou · 发表于：Ultrasound in Obstetrics and Gynecology · 年份：2020 · DOI：10.1002/uog.21990 · 被引用次数：31 · 研究领域：Fetal and Pediatric Neurological Disorders、Neonatal and fetal brain pathology、Prenatal Screening and Diagnostics

ABSTRACT Objective To create prescriptive growth standards for five fetal brain structures, measured using ultrasound, in healthy, well‐nourished women at low risk of impaired fetal growth and poor perinatal outcome, taking part in the Fetal Growth Longitudinal Study (FGLS) of the INTERGROWTH‐21 st Project. Methods This was a complementary analysis of a large, population‐based, multicenter, longitudinal study. The sample analyzed was selected randomly from the overall FGLS population, ensuring an equal distribution among the eight diverse participating sites and of three‐dimensional (3D) ultrasound volumes across pregnancy (range: 15–36 weeks' gestation). We measured, in planes reconstructed from 3D ultrasound volumes of the fetal head at different timepoints in pregnancy, the size of the parieto‐occipital fissure (POF), Sylvian fissure (SF), anterior horn of the lateral ventricle, atrium of the posterior horn of the lateral ventricle (PV) and cisterna magna (CM). Fractional polynomials were used to construct the standards. Growth and development of the infants were assessed at 1 and 2 years of age to confirm their adequacy for constructing international standards. Results From the entire FGLS cohort of 4321 women, 451 (10.4%) were selected at random. After exclusions, 3D ultrasound volumes from 442 fetuses born without a congenital malformation were used to create the charts. The fetal brain structures of interest were identified in 90% of cases. All structures, except the P...