Photocatalytic C–F Bond Borylation of Polyfluoroarenes with NHC-boranes

作者：Peng‐Ju Xia, Zhipeng Ye, Yuan‐Zhuo Hu, Jun‐An Xiao, Kai Chen, Hao‐Yue Xiang, Xiaoqing Chen, Hua Yang · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c00020 · 被引用次数：70 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Catalytic C–H Functionalization Methods

has been facilely achieved at room temperature via a single-electron-transfer (SET)/radical addition pathway. This new strategy makes full use of the advantage of photoredox catalysis to generate the key boryl radical via direct activation of a B-H bond. Good functional group tolerance and high regioselectivity offer this protocol incomparable advantages in preparing a wide array of valuable polyfluoroarylboron compounds. Moreover, both computational and experimental studies were performed to illustrate the reaction mechanism.