Dose controlled nitric oxide-based strategies for antibacterial property in biomedical devices

作者：Jayanti Mendhi, Mohammad Asgari, Greeshma Ratheesh, Indira Prasadam, Ying Yang, Yin Xiao · 发表于：Applied Materials Today · 年份：2020 · DOI：10.1016/j.apmt.2020.100562 · 被引用次数：42 · 研究领域：Analytical Chemistry and Sensors、Nanoplatforms for cancer theranostics、Advanced Sensor and Energy Harvesting Materials

Infections caused by bacterial adhesion and biofilms are a significant health and economic problem, resulting in considerable patient morbidity and mortality. Nitric oxide (NO), a small molecule and free radical, is known to be an antimicrobial agent that acts on bacteria via oxidative stress and release of peroxynitrites. These unique properties make NO release a simple and effective method to address bio-film associated clinical complications that frequently appears in the biomedical devices. Despite the usefulness of NO being established several years ago, there is still little translation into the clinical or medical scenario. This may be attributed to the dose sensitivity of NO. In this work, we have clearly summarized dose-dependent effects of NO and control mechanisms of NO release in biomedical devices. This review provides concise knowledge that helps in reducing the gap between research and clinical translation of NO use in biomedical devices.