Therapeutic mammaplasty is a safe and effective alternative to mastectomy with or without immediate breast reconstruction

作者：Shelley Potter, Adam Trickey, Tim Rattay, Rachel O’Connell, Rajiv Dave, Elizabeth A. Baker, Lisa Whisker, Joanna Skillman, Matthew Gardiner, R. Douglas Macmillan, Chris Holcombe, Shelley Potter, Adam Trickey, Tim Rattay, Rajiv Dave, Elizabeth A. Baker, Lisa Whisker, Joanna Skillman, Matthew Gardiner, R. Douglas Macmillan, Chris Holcombe, Nicola Barnes, Jane Blazeby, Elizabeth J. Conroy, Rajiv Dave, Matthew Gardiner, Adrian Harnett, Chris Holcombe, Shelley Potter, Tim Rattay, Joanna Skillman, Paula Williamson, Rajgopal Achuthan, Shweta Aggarwal, Elizabeth A. Baker, Naren Basu, Lisa Brock, Patricia Fairbrother, Matthew Gardiner, Chris Holcombe, Charlotte Ives, Abhilash Jain, Baek Kim, R. Douglas Macmillan, John Murphy, Shelley Potter, Tim Rattay, Dionysios-Dennis Remoundos, Richard Sutton, Adam Trickey, Philip Turton, Kathryn Williams, Alain Curnier, Amir Tadros, Ivan Depasquale, Mairi Fuller, Roger Bourne, Steven D. Heys, Ishrak Hamo, Fatima Aloraifi, Laura Fopp, Radhika Bali, Sarah E. Bache, Sarah Benyon, Michael S. Irwin, Amit Agrawal, Charles M. Malata, Claire Murphy, Adam T. Misky, Dennis Wayne Chicken, Nassreen Abdullah, Arnold D. Hill, Carolyn Cullinane, Gareth Irwin, Stuart McIntosh, Sigi Refsum, Samantha Sloan, Peter Mallon, Chiara Sirianni, Ilyas Khattak, Chiara Sirianni, Geerthan Nagachandra, Pasupathy Kiruparan, Debasish Debanth, Simon Davey, Terry‐Ann Curran, Matilda Svenning, Sasirekha Govindarajulu, Zenon Rayter, Rachel Ainsworth, Simon Cawthorn, Ajay Sahu, S.W. Wilson, Elena Prousskaia, Antonello Accurso, Nicola Rocco, Rosa Di Micco, Antonello Accurso, Gennaro Limite, Raffaele Ceccarino, Raffaele Liccardo, Guido Coco, Metin Nizamoglu, Mary Morgan, Venkat M. Ramakrishnan, Giuseppe Catanuto, Alex Wilkins, Penelope McManus, Peter Kneeshaw, Kartikae Grover, Tapan Mahapatra, Brendan Wooler, B Eyn Elahi, Naila Bint Ihsan, Alexandra Bucknor, Dimitris Reissis, Judith Hunter, Simon Wood, Navid Jallali, Francis P. Henry, Liaquat Suleman Verjee, Jason Lee, Shazia M Khan, Iman Azmy, Julia Massey, Ciaran Hollywood, Michael Oluwajana, Sonia Bathla, Joanna Seward, Claudia Harding-Mackean, Risha Lane, Kothandaraman Murali, Bashishta Biswas, Pawel Trapszo, Seema Seetharam, Katy Kennedy, Louise Alder, T. Graja, Khalid Amin, Jalal Kokan, Chandeena Roshanlall, Emma Gill, Dhananjay Kulkarni, J. Michael Dixon, Oliver Young, Talha Saleem, Martha Biddle, Marie Kearns, Eva Weiler-Mithoff, Ben Chew, Andy Malyon, John Scott, David J. McGill, Iain R. Mackay, Salena Bains, Sara Barrows, Tim Rattay, Simon Pilgrim, Sheila Shokuhi, Kelly Lambert, F.S. Kenny, Kalliope Valassiadou, Monika Kaushik, Jarosław Krupa, Dimitris Dragoumis, Pavlos Lampropoulos, S Moss, Haitham Khalil, Anwar Ul Haq, Balapathiran Balasubramanian, Petros Charalampoudis, Hisham Hamed, Ashutosh Kothari, Tibor Kovács, Michael Douek, Iftikhar Mehmood, Biswajit Ray, Matthew Adelekan, Laura Humphreys, Salim Tayeh, Christina Choy, Laila Parvanta, Silvia Michieletto, Tania Saibene, James E. O’Brien, Sue Down, Sarah Downey, Jerome Pereira, Amtul Salam Sami, A Gvaramadze, Jibril A Jibril, Dinesh Thekkinkattil, Sujatha Udayasankar, Saira Khawaja, Yousef Shariaha, Simon Holt, Ruth M. James, Hirah Rizki, Katharine Kirkpatrick, Duraisamy Ravichandran, Deepak Shrestha, Ellora Barua, Deepika Akolekar, Ahmed Hamad, Eleftheria Kleidi, S. Hignett, Vanessa Pope, Salma Naseem, Jennifer Isherwood, Rachel Soulsby, Amanda Taylor, Kian Chin, Dai Nguyen, Francesca Guest, Amanda Thorne, Valentina Lefemine, Chris Kirchhoff, Declan C. Murphy, Michelle Lo, R. B. Harcourt, Simon Pain, Maged Hussien, Katalin Zechmeister, E.M. Sassoon, Andrea Figus, Richard M. Haywood, Rozina Ali, Susanna Alexander, Adrian Harnett, K. Geropantas, Daniel Epurescu, Rebecca L. Lewis, Oladapo Fafemi, Jasdeep Gahir, Tasha Gandamihardja, Jennett Kelsall, Nazli Muhibullah, Charlene Otieno, Fayyaz Mazari, Marta D’Auria, Lisa Whisker, Douglas Macmillan, Eleanor Gutteridge, Tuabin Rasheed, Hazem Khout, Kristjan Asgeirsson, Stephen J. McCulley, Maria Donatella Mariniello, Manuela Roncella, Matteo Ghilli, Livio Colizzi, Elena Rossetti, Lo Russo Marzia, L. Fustaino, Alessandro Quattrini Li, Kate L Harvey, Rebecca C. Windle, Dionysios-Dennis Remoundos, Pankaj G. Roy, Gael MacLean, Asha Adwani, Elena G. Popa, Steven Goh, Geeta Shetty, Sarah E. Clark, Lorenzo Bernaudo, Avi Agrawal, Lucy Mansfield, Sally Tebbal, Ashraf Patel, Veronica Grassi, Ojas Pujji, Kathryn Hamnett, Naren Basu, Emily Granger, Michael Durbar, Panagiotis Pikoulas, Clare Garnsey, P.L. Walker, Angela J Vollermere, Ioannis Michalakis, Robin M. Jones, Mina Youssef, Charlotte Ives, Mohammad Masood, Julie Dunn, Sisse Olsen, Douglas Ferguson, Rachel Tillett, A. Allan, Alexander Woollard, Rebecca Canny, Alexander Woollard, Afshin Mosahebi, Stephen F. Hamilton, Jagdeep S. Chana, Nilesh M. Sojitra, Ibby Younis, Dick Rainsbury, Natalie Chand, Vasileios Kalles, Anne Stebbing, Kevin M. Harris, Siobhan Laws, Chris Holcombe, Anne Tansley, Geraldine M. Mitchell, Emma de Sousa, Julia Henderson, M. Chandrashekar, Bernadette Pereira, Chloe Constantinou, Dalia Elfadl, Foivos Irakleidis, Izaro Hernan, Miriam Byrne, Rachel O’Connell, Jennifer Rusby, Peter Barry, Katerine Krupa, William Allum, Fiona MacNeill, Nicola Roche, Gerald Gui, Kelvin Ramsey, Paul G. Harris, Stuart James, Shelley Potter, Richard Sutton, Jamie McIntosh, Nicola Laurence, Louise MacLennan, Robert A. Milligan, Henry Cain, Adam Critchley, Joe O’Donoghue, Loraine Kalra, Nick Collis, Gina Weston-Petrides, Roanne Fiddes, Victoria Tzortziou Brown, Anna Aertssen, Diana Slade-Sharman, Mansoor Khan, Caroline McGuiness, Vittoria Amorosi, Santanelli di Pompeo Fabio, Georgios Exarchos, Natasha Jiwa, Jennifer Hu, Serena Ledwidge, Laura Johnson, A L G Peel, Naseem Dhooma, Eric Farrell, Liam Devane, Ruth Tevlin, Enda McDermott, Ruth Prichard, Denis Evoy, Jane Rothwell, James Geraghty, Colin Morrison, Catriona Lawlor, Fiona Langlands, Lauren J. Taylor, Philip Turton, Raj Achuthan, Kieran Horgan, Shireen McKenzie, Brian Hogan, Mark Lansdown, Channegowda Navin, Liz Sherwin, Caroline Mortimer, Neeraj Garg, Rahma Adam, Tahera Arif, Zbigniew Kryjak, Deedar Ali, R Sowdi, Elena Fage, Senthurun Mylvaganam, Pilar Matey, Raghavan Vidya, Tapan Sircar, Oubida Asaad, Pud Bhaskar, Matei Dordea, Ada Chrysafi, Damian McCartan, Rajiv Dave, Rachel Foster, Rebecca L. Wilson, Sylvia Okwemba, Yousef Majeed, Ciara O’Brien, Vinod Mathen, John Murphy, Nicola Barnes, Ashu Gandhi, James Harvey, Cliona Kirwan, Richard S. Johnson, Krupali Patel, Maria Dalmau I Ribas, Natali Vigneswaran, Tom Challoner, Joanna Skillman, Alan Park, Maged Rizkalla, Abigail Tomlins, Kat McEvoy, Sadaf Jafferbhoy, Soni Soumian, Sankaran Narayanan, Robert Kirby, Sladana Bajrusevic, Joseph Maalo, M Charalambous, Lee Min Lai, K Chong, Simon Thomson, Sherif Monib, Leena Chagla, Riccardo A. Audisio, Rieka Taghizadeh, Azhar Iqbal, Karen James, Maria Callaghan, Shabbir Poonawala, Jonathan N. Lund, Raman Vinayagam, Sadaf Jafferbhoy, Steven Thrush, Rachel Bright Thomas, Michelle Mullan, Jevan Taylor, Ryo Yoshimura, Tom V. Mathew, Ben Mancey Jones, Kailas Munot, Rana Nasr, Jenny Piper, Deena El-Sharief, Mohammad Z. Mustafa, Caitlin S. MacLeod, Elizabeth Smyth, Ivan Depasquale, Mairi Fuller, Nina Saeed, Yazan Masannat, Amir Tan Mohd-Amin, Amit Agrawal, Gareth Irwin, Sam Sloan, Sigi Refsum, Stuart McIntosh, Abdulla Ibrahim, Ajay Sahu, Sasirekha Govindarajulu, Simon Cawthorn, Antonello Accurso, Rathi Rathinaezhil, Alex Wilkins, Eiman Khalifa, Kartikae Grover, Penny McManus, Peter Kneeshaw, Tapan Mahapatra, Iman Azmy, Julia Massey, Pawel Trapszo, Risha Lane, Seema Seetharam, Nicola Rocco, Chandeena Roshanlall, Jalal Kokan, Khalid Amin, Alexander Leeper, Dhananjay Kulkarni, J. Michael Dixon, Oliver Young, Talha Saleem, Jennifer McIlhenny, Andy Malyon, James Mansell, Keith Ogsto, Laszlo Romics, Dimitris Dragoumis, Jarosław Krupa, Kalliope Valassiadou, Kelly Lambert, Monika Kaushik, S Shokuhi, Simon Pilgrim, Xiang Wei Jonathan Lee, Asmaa Al‐Allak, Clare Fowler, Eleanore Massey, Fiona Court, Richard Hunt, Sarah Vestey, Haitham Khalil, Mohsen El-Gammal, Laila Parvanta, Amtul Salam Sami, A Gvaramadze, Dinesh Thekkinkattil, Katharine Kirkpatrick, Ruth M. James, Arish Noshirwani, Tehera Arif, Zbigniew Kryjak, Amanda Taylor, Fahd Syed, Gazalla Safdar, Kian Chin, Rachel Soulsby, Amanda Thorne, Francesca Guest, Mohammed El-Abbar, Fiona J. Hogg, Pauline McGee, Vassilis Pitsinis, Jenny Smith, Sundus Makkiyah, Syed Farrukh Mustafa, Charlene Otieno, Dana Photiou, Douglas Macmillan, Ellie Gutteridge, Fayyaz Mazari, Georgette Oni, Hazem Khout, Jennett Kelsall, K Hallam, Kristjan Asgeirron, Lisa Whisker, Marta D’Auria, Samim Al-zubaidi, Stephen J. McCulley, Tuabin Rasheed, James A. Bailey, Lisa Brock, Nazli Muhibullah, Alexandra Tenovici, Dionysios-Dennis Remoundos, Nikos Chaidos, Oana Predescu, Pankaj G. Roy, Rebecca C. Windle, Elena G. Popa, Geeta Shetty, J Rezulski, Steven Goh, Tholkifl Abdullah, Dinesh Thekkinkattil, Saira Khawaja, Sujatha Udayasankar, Sally Tebbal, Veronica Grassi, Adam Talbot, Naren Basu, Jagdeep Singh, Amy C. Smith, Angela Volleamere, Clare Garnsey, Panagiotis Pikoulas, Charlotte Ives, Douglas Ferguson, Rachel Tillett, Sarah Dean, Sisse Olsen, Dick Rainsbury, Lashan Peiris, Olivia Sjökvist, Siobhan Laws, Anne Tansley, Emma de Sousa, Geraldine M. Mitchell, Julia Henderson, M. Chandrashekar, Shelley Potter, Aikaterini Micha, Amy Godden, Bernadette Pereira, Chloe Constantinou, Jennifer Rusby, Katherine Krupa, Peter Barry, Adam Critchley, Baek Kim, Henry Cain, Joe O’Donoghue, J. Henton, Loraine Kalra, Louise MacLennan, Ruth Bennett, S Nicholson, Guido Paolini, L. Renzi, Santanelli Di Pompeo, Vitto Ria, Jennifer Hu, Laura Johnson, Rebecca S. Lewis, Sirwan Hadad, Anup Sharma, Delia Toomey, Dibyesh Banerjee, Sarah Shuk Kay Tang, Lauren J. Taylor, Philip Turton, Raj Achuthan, Shireen McKenzie, Tanvir Ahmad, Kate Williams, Mohammed Absar, Nabila Nasir, Igor J. Rychlik, Lynn Darragh, Ruth Johnston, Stephen Kirk, Jacqueline Rees-Lee, Michael Green, Abhishek Sharma, K Chong, Lee Min Lai, Jia Choong, Shweta Aggarwal, Zaker Ullah, Leena Chagla, Ommen Koshy, Sonia Bathla, Tamara Kiernan, Ajay Ashok Bhojwani, Jonathan N. Lund, Maria Callaghan, Raman Vinayagam, Shabbir Poonawala, Jevan Taylor, Michelle Mullan, Rachel Bright-Thomas, Ashu Gandhi, Ged Byrne, Ibrahim Ibrahim, James Harvey, John Murphy, Lyndsey Highton, Ada Chrysafi, Owen James Morris, Sumohan Chatterjee, Vinod Mathen, Yousef Majeed, Cliona Kirwan, B. Mancey-Jones, D El Sharief, Kailas Munot, Rana Nasr, Richard Frame · 发表于：British journal of surgery · 年份：2020 · DOI：10.1002/bjs.11468 · 被引用次数：40 · 研究领域：Breast Implant and Reconstruction、Reconstructive Surgery and Microvascular Techniques、Breast Cancer Treatment Studies

BACKGROUND: Therapeutic mammaplasty (TM) may be an alternative to mastectomy, but few well designed studies have evaluated the success of this approach or compared the short-term outcomes of TM with mastectomy with or without immediate breast reconstruction (IBR). Data from the national iBRA-2 and TeaM studies were combined to compare the safety and short-term outcomes of TM and mastectomy with or without IBR. METHODS: The subgroup of patients in the TeaM study who underwent TM to avoid mastectomy were identified, and data on demographics, complications, oncology and adjuvant treatment were compared with those of patients undergoing mastectomy with or without IBR in the iBRA-2 study. The primary outcome was the percentage of successful breast-conserving procedures in the TM group. Secondary outcomes included postoperative complications and time to adjuvant therapy. RESULTS: A total of 2916 patients (TM 376; mastectomy 1532; mastectomy and IBR 1008) were included in the analysis. Patients undergoing TM were more likely to be obese and to have undergone bilateral surgery than those having IBR. However, patients undergoing mastectomy with or without IBR were more likely to experience complications than the TM group (TM: 79, 21·0 per cent; mastectomy: 570, 37·2 per cent; mastectomy and IBR: 359, 35·6 per cent; P < 0·001). Breast conservation was possible in 87·0 per cent of patients who had TM, and TM did not delay adjuvant treatment. CONCLUSION: TM may allow high-risk patients w...