STAT3 signaling in ovarian cancer: a potential therapeutic target

作者：Renba Liang, Xishan Chen, Li Chen, Fangzhu Wan, Kai-Hua Chen, Yongchu Sun, Xiaodong Zhu · 发表于：Journal of Cancer · 年份：2019 · DOI：10.7150/jca.35011 · 被引用次数：94 · 研究领域：Cytokine Signaling Pathways and Interactions、Cancer Mechanisms and Therapy、Ovarian cancer diagnosis and treatment

Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3 (STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently overexpressed in a wide range of cancer cells as well as clinical specimens, promoting tumor progression. It is widely accepted that STAT3 regulates a variety of cellular processes, such as tumor cell growth, survival, invasion, cancer stem cell-like characteristic, angiogenesis and drug-resistance. In this review, we focus on the role of STAT3 in tumorigenesis in ovarian cancer and discuss the existing inhibitors of STAT3 signaling that can be promisingly developed as the strategies for ovarian cancer therapy.