Clinical characteristics of 2019 novel coronavirus infection in China

作者：Wei‐jie Guan, Zhengyi Ni, Yu Hu, Wenhua Liang, Chun‐Quan Ou, Jianxing He, Lei Liu, Hong Shan, Chunliang Lei, David S.C. Hui, Bin Du, Lanjuan Li, Guang Zeng, Kwok‐Yung Yuen, Ruchong Chen, Chunli Tang, Tao Wang, Pingyan Chen, Jie Xiang, Shiyue Li, Jinlin Wang, Zijing Liang, Yixiang Peng, Li Wei, Yong Liu, Yahua Hu, Peng Peng, Jianming Wang, Jiyang Liu, Zhong Chen, Gang Li, Zhijian Zheng, Shaoqin Qiu, Jie Luo, Chang-jiang Ye, Shaoyong Zhu, Nanshan Zhong · 发表于：medRxiv · 年份：2020 · DOI：10.1101/2020.02.06.20020974 · 被引用次数：1488 · 研究领域：COVID-19 Clinical Research Studies、SARS-CoV-2 and COVID-19 Research、COVID-19 diagnosis using AI

Abstract Background Since December 2019, acute respiratory disease (ARD) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought to delineate the clinical characteristics of these cases. Methods We extracted the data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD from 552 hospitals in 31 provinces/provincial municipalities through January 29 th , 2020. Results The median age was 47.0 years, and 41.90% were females. Only 1.18% of patients had a direct contact with wildlife, whereas 31.30% had been to Wuhan and 71.80% had contacted with people from Wuhan. Fever (87.9%) and cough (67.7%) were the most common symptoms. Diarrhea is uncommon. The median incubation period was 3.0 days (range, 0 to 24.0 days). On admission, ground-glass opacity was the typical radiological finding on chest computed tomography (50.00%). Significantly more severe cases were diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal radiological findings than non-severe cases (23.87% vs. 5.20%, P <0.001). Lymphopenia was observed in 82.1% of patients. 55 patients (5.00%) were admitted to intensive care unit and 15 (1.36%) succumbed. Severe pneumonia was independently associated with either the admission to intensive care unit, mechanical ventilation, or death in multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 to 23.67). Conclusions The 2019-nCoV epi...