Initial pH and shockable rhythm are associated with favorable neurological outcome in cardiac arrest patients resuscitated with extracorporeal cardiopulmonary resuscitation

作者：Oussama Daou, Hadrien Winiszewski, Guillaume Besch, Sébastien Pili‐Floury, François Belon, Benoît Guillon, Tania Marx, Sidney Chocron, Gilles Capellier, Andréa Perrotti, Gaël Piton · 发表于：Journal of Thoracic Disease · 年份：2020 · DOI：10.21037/jtd.2019.12.127 · 被引用次数：51 · 研究领域：Mechanical Circulatory Support Devices、Cardiac Arrest and Resuscitation、Cardiac Ischemia and Reperfusion

BACKGROUND: There is uncertainty about best selection criteria for extracorporeal cardiopulmonary resuscitation (eCPR) in the setting of refractory cardiac arrest. We aimed to identify factors associated with a favorable neurological outcome, and to build a score calculable at the time of ECMO insertion predicting the prognosis. METHODS: Retrospective analysis of all patients who underwent eCPR between 2010 and 2017 in a single university hospital. Primary end point was survival with favorable neurological outcome at intensive care unit (ICU) discharge defined as a Cerebral Performance Category of 1 or 2. RESULTS: Overall low-flow time of the 113 included patients was 84 [55-122] minutes. Eighteen patients (16%) survived with a favorable neurological outcome. By multivariate logistic regression analysis, initial shockable rhythm, and arterial blood pH at the time of eCPR implantation ≥7.0, were independent predictors of survival with favorable neurological outcome. All of the patients presenting with both non-shockable rhythm and pH <7.0 at the time of eCPR implantation died in the ICU. CONCLUSIONS: At the time of eCPR start, only initial shockable rhythm and arterial pH ≥7.0 predicted neurological outcome. A selection of the patients who might benefit from eCPR, based upon initial rhythm and arterial pH rather than on low flow time, should be further evaluated.