Utility of Diffusion‐Weighted Imaging for Guiding Clinical Management of Patients With Kidney Transplant: A Prospective Study

作者：Xuefeng Ni, Wei Wang, Xue Li, Yanjun Li, Jinsong Chen, Donghong Shi, Jiqiu Wen · 发表于：Journal of Magnetic Resonance Imaging · 年份：2020 · DOI：10.1002/jmri.27071 · 被引用次数：15 · 研究领域：MRI in cancer diagnosis、Renal and Vascular Pathologies、Advanced MRI Techniques and Applications

Background Although biopsy is essential for the diagnosis and management of kidney transplant recipients, it is invasive. Intravoxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) is a noninvasive technique that can assess both capillary perfusion and tissue diffusion. Purpose To evaluate the capability of IVIM‐DWI as a differentiation of kidney transplant patients who need clinical intervention from those who need not. Study Type Prospective. Subjects In all, 33 kidney transplant patients who needed clinical intervention and 19 who need not. Field Strength/Sequence 3.0T; IVIM‐DWI with a single‐shot echo planar imaging sequence. Assessment All patients underwent kidney transplant biopsy and IVIM‐DWI scans. Patients were dichotomized into those who needed clinical intervention (CHANGE group) and those who need not (Non‐CHANGE group) based on biopsy results. The values of total apparent diffusion coefficient (ADC T ), diffusion coefficient (D), and perfusion fraction (f) were acquired from renal cortex and medulla, respectively. The area under the curve (AUC) was calculated and compared. Statistical Tests Independent Student's t ‐test, receiver‐operating characteristic curve, and Spearman correlation analysis. Results All the cortical and medullary DWI parameters in the CHANGE group were significantly lower than those in the Non‐CHANGE group (all P ≤ 0.012). Except for medullary fp, all DWI parameters in both the cortex and the medulla were inversely correlated with bo...