Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

作者：Geneviève Pépin, Dominic De Nardo, Christina L. Rootes, Tomalika R. Ullah, Sumaiah S. Al-Asmari, Katherine R. Balka, Hongmei Li, Kylie M. Quinn, Fiona Moghaddas, Stéphane Chappaz, Benjamin T. Kile, Eric F. Morand, Seth L. Masters, Cameron R. Stewart, Bryan R.G. Williams, Michael P. Gantier · 发表于：mBio · 年份：2020 · DOI：10.1128/mbio.03187-19 · 被引用次数：68 · 研究领域：interferon and immune responses、Viral Infections and Vectors、Viral Infections and Outbreaks Research

Recent studies suggest that extracellular cGAMP can be taken up by macrophages to engage STING through several mechanisms. Our work demonstrates that connexin-dependent communication between epithelial cells and macrophages plays a significant role in the amplification of antiviral responses mediated by cGAMP and suggests that pharmacological strategies aimed at modulating connexins may have therapeutic applications to control antiviral responses in humans.