Cerebrospinal fluid influx drives acute ischemic tissue swelling

作者：Humberto Mestre, Ting Du, Amanda M. Sweeney, Guojun Liu, Andrew J. Samson, Weiguo Peng, Kristian Nygaard Mortensen, Frederik Filip Stæger, Peter A. R. Bork, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, John H. Thomas, Poul G. Hjorth, Erik A. Martens, Rupal I. Mehta, Orestes E. Solis, Pablo Blinder, David Kleinfeld, Hajime Hirase, Yuki Mori, Maiken Nedergaard · 发表于：Science · 年份：2020 · DOI：10.1126/science.aax7171 · 被引用次数：506 · 研究领域：Cerebrospinal fluid and hydrocephalus、Neuroscience of respiration and sleep、Traumatic Brain Injury and Neurovascular Disturbances

Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.