Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

作者：Haibin Li, Deqiang Zheng, Zhiwei Li, Zhiyuan Wu, Wei Feng, Xue Cao, Jiaxin Wang, Qi Gao, Xia Li, Wei Wang, Brian J. Hall, Yu‐Tao Xiang, Xiuhua Guo · 发表于：JAMA Network Open · 年份：2019 · DOI：10.1001/jamanetworkopen.2019.16591 · 被引用次数：402 · 研究领域：Cardiac Health and Mental Health、Cardiovascular Health and Risk Factors、Mental Health Treatment and Access

Importance: The prevalence of depressive symptoms among older adults has become an increasingly important public health priority. Elevated depressive symptoms are well documented among elderly people with cardiovascular disease (CVD), but studies conducted among Chinese adults are scarce. Objective: To estimate the association between depressive symptoms and incident CVD among middle-aged and older Chinese adults. Design, Setting, and Participants: The China Health and Retirement Longitudinal Study is an ongoing nationally representative prospective cohort study that was initiated in 2011. This cohort study included 12 417 middle-aged and older Chinese adults without heart disease and stroke at baseline. Statistical analysis was conducted from April 25, 2018, to December 13, 2018. Exposure: Depressive symptoms were assessed using the validated 10-item of Center for Epidemiologic Studies Depression Scale. Main Outcomes and Measures: Incident CVD (ie, self-reported physician-diagnosed heart disease and stroke combined) was followed-up from June 1, 2011, to June 31, 2015. The Center for Epidemiologic Studies Depression Scale total score ranges from 0 to 30, with a score of 12 or more indicating elevated depressive symptoms. Results: Of the 12 417 participants (mean [SD] age at baseline, 58.40 [9.51] years), 6113 (49.2%) were men. During the 4 years of follow-up, 1088 incident CVD cases were identified. Elevated depressive symptoms were independently associated with an increased ...