The dual-catalyzed boryldifluoroallylation of alkynes: an efficient method for the synthesis of skipped gem -difluorodienes

作者：Kai‐Feng Zhuo, Wenyan Xu, Tian‐Jun Gong, Yao Fu · 发表于：Chemical Communications · 年份：2020 · DOI：10.1039/c9cc08485a · 被引用次数：32 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Organoboron and organosilicon chemistry

The Cu/Pd-catalyzed boryldifluoroallylation of alkynes was achieved, providing the corresponding skipped gem-difluorodiene scaffolds with high regio- and stereoselectivity in moderate to excellent yields. This new approach has good functional group compatibility for both alkynes and 3,3-difluoro-substituted allylic esters. Moreover, an array of synthetic building blocks, skipped dienes, trienes, and drug mimics can be obtained via further transformations.