MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma

作者：Zhuochao Liu, Junxiang Wen, Chuanlong Wu, Chuanzhen Hu, Jun Wang, Qiyuan Bao, Hongyi Wang, Jizhuang Wang, Qi Zhou, Wei Li, Yuhui Shen, Weibin Zhang · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.102679 · 被引用次数：36 · 研究领域：Cancer Immunotherapy and Biomarkers、Cancer-related molecular mechanisms research、MicroRNA in disease regulation

cytotoxic T lymphocytes. But microRNA-200a overexpression group was also more responsive to PD-L1-targeted immunotherapy than the controls. In addition, the tumor tissues from 32 osteosarcoma patients showed that high expression of microRNA-200a and PD-L1 was associated with poor tumor necrosis rate after chemotherapy. Moreover, we confirmed that tensin homolog deleted on chromosome ten (PTEN) could act as the target gene for microRNA-200a during the upregulation of PD-L1. Thus, our findings provide important and novel insight into a regulatory axis involving microRNA-200a/PTEN/ PD-L1 axis, which determines osteosarcoma growth and the efficacy of PD-L1-targeted immunotherapy.