Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

作者：Mudassir Shah, Chunxiao Sun, Zichao Sun, Guojian Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li · 发表于：Marine Drugs · 年份：2020 · DOI：10.3390/md18020071 · 被引用次数：37 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Plant Pathogens and Fungal Diseases

Three new polyketides, ketidocillinones A–C (1–3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1−3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL.