Oxidative Coupling of Diazo and NH 4 I: A Route to Primary Oxamates and α-Ketoamides

作者：Hanghang Wang, Yanwei Zhao, Yonggao Zheng, Shangwen Fang, Jingjing Li, Xiaobing Wan · 发表于：The Journal of Organic Chemistry · 年份：2020 · DOI：10.1021/acs.joc.9b02952 · 被引用次数：27 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions

A simple and efficient method has been developed for the preparation of primary oxamates and α-ketoamides through the oxidative coupling of diazo compounds and NH 4 I. Under the optimized reaction conditions, a range of diazoesters and α-diazoketones was explored, and the corresponding products were obtained in moderate to good yields. This protocol is metal-free, is performed under mild conditions, has a wide substrate scope, and offers operational simplicity.