MR Diffusional Kurtosis Imaging–Based Assessment of Brain Microstructural Changes in Patients with Moyamoya Disease before and after Revascularization

作者：Peng‐Gang Qiao, Xu Cheng, Gongjie Li, Peiji Song, Cong Han, Zhenghan Yang · 发表于：American Journal of Neuroradiology · 年份：2020 · DOI：10.3174/ajnr.a6392 · 被引用次数：12 · 研究领域：Advanced Neuroimaging Techniques and Applications、Moyamoya disease diagnosis and treatment、Cerebrovascular and Carotid Artery Diseases

BACKGROUND AND PURPOSE: Conventional imaging examinations are insufficient to accurately assess brain damage in patients with Moyamoya disease. Our aim was to observe brain microstructural changes in patients with Moyamoya disease by diffusional kurtosis imaging and provide support data for application of this technique in individualized assessment of disease severity and surgical outcome among patients with Moyamoya disease. MATERIALS AND METHODS: A total of 64 patients with Moyamoya disease and 15 healthy volunteers underwent diffusional kurtosis imaging, and a second scanning was offered to surgical patients 3-4 months after revascularization. The diffusional kurtosis imaging parameter maps were obtained for mean kurtosis, axial kurtosis, radial kurtosis, fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. The parameter values were measured in sensory pathway-related regions for all subjects. Differences in diffusional kurtosis imaging parameters of these brain regions were examined for healthy volunteers, patients without acroparesthesia, and asymptomatic and symptomatic sides of patients with acroparesthesia. Changes in diffusional kurtosis imaging parameters of patients with Moyamoya disease before and after revascularization were compared. RESULTS: Compared with healthy volunteers, patients with Moyamoya disease showed decreased mean kurtosis, axial kurtosis, radial kurtosis, and fractional anisotropy in the corona radiata. Similarly, me...