Nanotherapy: Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 (Adv. Mater. 46/2019)

作者：Huimin Li, Huilin Guo, Chang Lei, Li Liu, Liqin Xu, Yaping Feng, Ke Jin, Wei Fang, Hao Song, C. F. Xu, Chengzhong Yu, Xing Long · 发表于：Advanced Materials · 年份：2019 · DOI：10.1002/adma.201970331 · 被引用次数：8 · 研究领域：Osteoarthritis Treatment and Mechanisms

In article number 1904535, Chun Xu, Chengzhong Yu, Xing Long, and co-workers report a new strategy to promote endogenous production of hyaluronic acid for the management of osteoarthritis by delivering hyaluronan synthase type 2 into the synoviocytes of joints using biodegradable mesoporous silica nanoparticles. This nanotherapy also helps in the repair of bone defects in a rat osteoarthritis bone-defect model.