Synthesis of Spiro[5.n (n=6–8)]heterocycles through Successive Ring‐Expansion/Indole C‐2 Functionalization

作者：Yang Yuan, Zixia Guo, Yuanyang Mu, Ye Wang, Murong Xu, Yanzhong Li · 发表于：Advanced Synthesis & Catalysis · 年份：2020 · DOI：10.1002/adsc.201901631 · 被引用次数：20 · 研究领域：Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions、Asymmetric Synthesis and Catalysis

Abstract A cascade procedure for the efficient and atom‐economical synthesis of spiro[5.n (n=6–8)]heterocycles has been developed. This process goes through the tandem reactions of base‐promoted ring‐expansion of cyclic ketones followed by Cu‐catalyzed intramolecular C‐2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol. magnified image