Protocols for a systematic review and network meta-analysis of antithrombotic therapy strategies for atrial fibrillation patients undergoing percutaneous coronary intervention v2

作者：Xiaoxuan Gong, Shaowen Tang, Jiangjin Li, Xiwen Zhang, Xiaoyi Tian, Shuren Ma · 年份：2017 · DOI：10.17504/protocols.io.iijcccn · 研究领域：Health Systems, Economic Evaluations, Quality of Life、Atrial Fibrillation Management and Outcomes

Objective:To evaluate the comparative efficacy and safety of antiplatelet agents, vitamin K antagonist (VKA) and non-VKA oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). Methods: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials will besearched to identify clinical trials comparing antiplatelet drugs with VKA and NOACs or their combination in AF patients undergoing PCI with a mean/median follow-up of at least 12 months. A network meta-analysis willbeconducted to directly and indirectly compare the efficacy and safety of competitive antithrombotic regimens with a Bayesian random-effects model.