Cobalt-Catalyzed Migrational Isomerization of Styrenes

作者：Jiajin Zhao, Biao Cheng, Chen‐Hui Chen, Zhan Ling Lu · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.9b04305 · 被引用次数：62 · 研究领域：Catalytic C–H Functionalization Methods、Synthetic Organic Chemistry Methods、Catalytic Cross-Coupling Reactions

An efficient cobalt-catalyzed migrational isomerization of styrenes was developed using the thiazoline iminopyridine (TIP) ligand. This reaction is operationally simple and atom-economical using readily available starting materials to access trisubstituted alkenes. Even when using a 0.1 mol % catalyst loading, the reaction could be conducted in neat and completed in 1 h with excellent conversion and high E stereoselectivity.