Quantitative evaluation of postintervention foot blood supply in patients with peripheral artery disease by computed tomography perfusion

作者：Ming Li, Zheng Li, Pan Gao, Liang Jin, Li Li, Wei Zhao, Wan Zhang, Yingli Sun, Yun Zhao, Jiasen Cui · 发表于：Journal of Vascular Surgery · 年份：2020 · DOI：10.1016/j.jvs.2019.11.030 · 被引用次数：15 · 研究领域：Peripheral Artery Disease Management、Diabetic Foot Ulcer Assessment and Management、MRI in cancer diagnosis

Objective The aim of this study was to quantitatively evaluate the changes of the foot's blood supply after endovascular treatment in patients with peripheral artery disease (PAD) using foot computed tomography (CT) perfusion. Methods Nineteen patients who underwent endovascular treatment for PAD between January 2018 and November 2018 were included in the study. Perfusion CT scanning was performed before and after intervention with the measurement of ankle-brachial index. Regions of interest were selected from two arteries and four different tissues per foot. Perfusion maps of blood volume, blood flow, permeability surface area product, time to peak (TTP), mean transit time (MTT), mean slope of increase (MSI), Tmax, and impulse response function (IRFt 0 ) were constructed and calculated by the perfusion analysis software. Wilcoxon signed rank test was performed on the eight parameter pairs of the limbs on the treated and untreated sides before and after intervention in the 19 patients. Results Differences in blood flow, MTT, TTP, Tmax, MSI, and IRFt 0 on the treated side of the tissue perfusion group and statistical difference in blood flow, MTT, and MSI on the treated side of the arterial perfusion group were observed (all P < .05). Ankle-brachial index improved from 0.41 ± 0.11 to 0.76 ± 0.10 ( P < .001). For the untreated side, TTP of the tissue perfusion group was significantly shortened (by 7.71 seconds) after surgery ( P = .006), whereas there were no differences in the...