Characterization of dermal skin innervation in fibromyalgia syndrome

作者：Dimitar Evdokimov, Philine Dinkel, Johanna Frank, Claudia Sommer, Nurcan Üçeyler · 发表于：PLoS ONE · 年份：2020 · DOI：10.1371/journal.pone.0227674 · 被引用次数：22 · 研究领域：Fibromyalgia and Chronic Fatigue Syndrome Research、Connective tissue disorders research、Psychosomatic Disorders and Their Treatments

INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS: In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION: We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients.