Kaixinsan, a Well-Known Chinese Herbal Prescription, for Alzheimer's Disease and Depression: A Preclinical Systematic Review

作者：Huan Fu, Zhen Xu, Xile Zhang, Guo‐qing Zheng · 发表于：Frontiers in Neuroscience · 年份：2020 · DOI：10.3389/fnins.2019.01421 · 被引用次数：52 · 研究领域：Medicinal Plants and Neuroprotection、Medicinal Plants and Bioactive Compounds、Tryptophan and brain disorders

Alzheimer’s disease (AD), the most common cause of dementia, is highly prevalent worldwide with no modifying therapy. Behavioral and psychological symptoms of dementia (BPSD) occur in most patients with AD, and depression is one of the most common AD-related BPSD. Kaixinsan (KXS) is an ancient Chinese herbal prescription widely used to treat dementia and forgetfulness. In this systematic review, we conducted a meta-analysis to assess preclinical evidence for the effects of KXS on cognitive impairment and depression. Thirty-eight articles involving 1050 animals were included after searching from six databases from the inception up to June 2019. The primary outcome measures were behavioral outcome. Indicators of cognitive function in AD included escape latency, time spent on the target quadrant, and the number of target platform crossings in the Morris water maze (MWM) test. Indicators of depression included number of rearing events and total distance in the open-field test, duration of immobility in the forced swim test, and sucrose consumption or sucrose preference index in the sucrose preference test. The secondary outcomes were mechanisms of KXS for treatment of AD and depression. The results showed that KXS significantly reduced escape latency (P<0.01), increased time spent in the target quadrant (P<0.01), and increased the number of target platform crossings (P<0.01) in the MWM test in AD models compared with control. The possible mechanisms for KXS-mediated improvements ...