The Immune Landscape of Cancer

作者：Vésteinn Thórsson, David L. Gibbs, Scott D. Brown, Denise M. Wolf, Dante S. Bortone, Tai-Hsien Ou Yang, Eduard Porta‐Pardo, Galen F. Gao, Christopher L. Plaisier, James A. Eddy, Elad Ziv, Aedín C. Culhane, Evan Paull, I.K. Ashok Sivakumar, Andrew J. Gentles, Raunaq Malhotra, Farshad Farshidfar, Antonio Colaprico, Joel S. Parker, Lisle E. Mose, Nam S. Vo, Jianfang Liu, Yuexin Liu, Janet Sue Rader, Varsha Dhankani, Sheila M. Reynolds, Reanne Bowlby, Andrea Califano, Andrew D. Cherniack, Dimitris Anastassiou, Davide Bedognetti, Younes Mokrab, Aaron M. Newman, Arvind Rao, Ken Chen, Alexander Krasnitz, Hai Dong Hu, Tathiane Maistro Malta, Houtan Noushmehr, Chandra Sekhar Pedamallu, Susan Bullman, Akinyemi I. Ojesina, Andrew E. Lamb, Wanding Zhou, Hui Shen, Toni K. Choueiri, John N. Weinstein, Justin Guinney, Joel Haskin Saltz, Robert A. Holt, Charles S. Rabkin, Rory Johnson, John A. Demchok, Ina Felau, Melpomeni Kasapi, Martin L. Ferguson, Carolyn M. Hutter, Heidi J. Sofia, Roy W Tarnuzzer, Zhining Wang, Liming M Yang, Jean Claude Zenklusen, Jiashan Zhang, Sudha Chudamani, Jia Liu, Laxmi Lolla, Rashi Naresh, Todd Pihl, Qiang Sun, Yunhu Wan, Ye Wu, Juok Cho, Timothy Defreitas, Scott Frazer, Nils Gehlenborg, Gad A. Getz, David I. Heiman, Jaegil Kim, Michael S. Lawrence, Pei Yi Lin, Sam Meier, Michael S. Noble, Gordon Saksena, Doug Voet, Hailei Zhang, Brady M. Bernard, Nyasha Chambwe, Varsha Dhankani, Theo Knijnenburg, Roger Kramer, Kalle Leinonen, Yuexin Liu, Michael J. Miller, Sheila M. Reynolds, Ilya Shmulevich, Vésteinn Thórsson, Wei Zhang, Rehan Akbani, Bradley McIntosh Broom, Apurva M. Hegde, Zhenlin Ju, Rupa S. Kanchi, Anil Korkut, Jun Li, Han Liang, Shiyun Ling, Wenbin Liu, Yiling Lu, Gordon Brent Mills, Kwok-Shing Ng, Arvind Rao, Michael P. Ryan, Jing Wang, John N. Weinstein, Jiexin Zhang, Adam A. Abeshouse, Joshua Armenia, Debyani Chakravarty, Walid Khaled Chatila, Ino de Bruijn, Galen F. Gao, Benjamin E Gross, Zachary J. Heins, Ritika Kundra, Konnor La, Marc Ladanyi, Augustin Luna, Moriah G. Nissan, Angelica Ochoa, Sarah M. Phillips, Ed Reznik, Francisco Sánchez-Vega, Chris Sander, Nikolaus D. Schultz, Robert E. Sheridan, Selçuk Onur Sümer, Yichao Sun, Barry S. Taylor, Jioajiao Wang, Hongxin Zhang, Pavana Anur, Myron Peto, Paul T. Spellman, Christopher C. Benz, Joshua M. Stuart, Christopher K. Wong, Christina S. F. Yau, David Neil Hayes, Joel S. Parker, Matthew D. Wilkerson, Adrian Ally, Miruna Balasundaram, Reanne Bowlby, Denise Brooks, Rebecca Birch Carlsen, Eric Chuah, Noreen Dhalla, Robert A. Holt, Steven J.M. Jones, Katayoon Kasaian, Darlene Lee, Yussanne Ma, Marco A. Marra, Michael L. Mayo, Richard A. Moore, Andrew J. J. Mungall, Karen Mungall, A. Gordon Robertson, Sara Sadeghi, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Kane Tse, Tina Wong, Ashton C. Berger, Rameen Beroukhim, Andrew D. Cherniack, Carrie Cibulskis, Stacey L. Gabriel, Galen F. Gao, Gavin Ha, Matthew M. Meyerson, Steven E. Schumacher, Juliann Shih, Melanie H. Kucherlapati, Raju Kucherlapati, Stephen B. Baylin, Leslie Cope, Ludmila Danilova, Moiz S. Bootwalla, Phillip H. Lai, Dennis T. Maglinte, David Van Den Berg, Daniel J. Weisenberger, J. Todd Auman, Saianand Balu, Tom Bodenheimer, Cheng Fan, Katherine A. Hoadley, Alan P. Hoyle, Stuart R. Jefferys, Corbin D. Jones, Shaowu Meng, Piotr A. Mieczkowski, Lisle E. Mose, Amy H. Perou, Charles M. Perou, Jeffrey M. Roach, Yan Shi, Janae V. Simons, Tara J. Skelly, Matthew G. Soloway, Donghui Tan, Umadevi Veluvolu, Huihui Fan, Toshinori Hinoue, Peter W. Laird, Hui Shen, Wanding Zhou, Michelle Bellair, Kyle Chang, Kyle R. Covington, Chad J. Creighton, Huyen Dinh, HarshaVardhan Doddapaneni, Lawrence A. Donehower, Jennifer Drummond, Richard A. Gibbs, Robert Glenn, Walker Hale, Yi Han, Hai Dong Hu, Viktoriya Korchina, Sandra Lee, Lora R Lewis, Wei Li, Xiuping Liu, Margaret Morgan, Donna Morton, Donna Marie Muzny, Jireh Santibanez, Margi Sheth, Eve Shinbrot, Linghua Wang, Min Wang, David A. Wheeler, Xi Liu, Fengmei Zhao, Julian M. Hess, Elizabeth L. Appelbaum, Matthew H. Bailey, Matthew G. Cordes, Li Ding, Catrina C. Fronick, Lucinda A. Fulton, Robert S. Fulton, Cyriac Kandoth, Elaine R. Mardis, Michael D. McLellan, Christopher A. Miller, Heather K. Schmidt, Richard K. Wilson, Daniel F. Crain, Erin E. Curley, Johanna Gardner, Kevin R Lau, David W. Mallery, Scott J. Morris, Joseph D. Paulauskis, Robert James Penny, Candace Shelton, Troy Shelton, Mark E. Sherman, Eric N. Thompson, Peggy Yena, Jay Bowen, Julie M. Gastier‐Foster, Mark Gerken, Kristen Leraas, Tara M. Lichtenberg, Nilsa C. Ramirez, Lisa Wise, Erik J. Zmuda, Niall M. Corcoran, Tony Costello, Christopher M. Hovens, André Lopes Carvalho, Ana Carolina de Carvalho, José Humberto Tavares Guerreiro Fregnani, Adhemar Longatto‐Filho, Rui Manuel Reis, Cristovam Scapulatempo‐Neto, Henrique C.S. Silveira, Daniel Onofre Vidal, Andrew Burnette, Jennifer Eschbacher, Beth Hermes, Ardene Noss, Rosy Singh, Matthew Linley Anderson, Patricia D. Castro, Michael Ittmann, David D. Huntsman, Bernard Kohl, Xuan Le, Richard Thorp, Chris Andry, Elizabeth R. Duffy, Vladimir Konstantinovich Lyadov, Oxana V. Paklina, Galiya R. Setdikova, Shabunin Av, Mikhail Mikhailovich Tavobilov, Christopher M. McPherson, Ronald E. Warnick, Ross Stuart Berkowitz, Daniel Cramer, Colleen M. Feltmate, Neil Stuart Horowitz, Adam Stuart Kibel, Michael George Muto, Chandrajit P. Raut, Andrei Malykh, Jill S. Barnholtz‐Sloan, Wendi Barrett, Karen Devine, Jordonna Fulop, Quinn T. Ostrom, Kristen Shimmel, Yingli Wolinsky, Andrew Edward Sloan, Agostino Maria De Rose, Felice Giuliante, Marc T. Goodman, Beth Y. Karlan, Curt H. Hagedorn, John A. Eckman, Jodi L. Harr, Jerome Myers, Kelinda Tucker, Leigh Anne Zach, Brenda Deyarmin, Hai Dong Hu, Leonid Kvecher, Caroline Larson, Richard Mural, Stella Somiari, Aleš Vícha, Tomáš Zelinka, Joseph Bennett, Mary Iacocca, Brenda Rabeno, Patricia Swanson, Mathieu Latour, Louis Lacombe, Bernard Têtu, Alain Bergeron, Mary McGraw, Susan M. Staugaitis, John A. Chabot, Hanina H. Hibshoosh, Antonia Rogado Sepulveda, Tao Su, Timothy Cragin Wang, Olga Potapova, Olga Voronina, Laurence Desjardins, Odette Mariani, Sergio Roman‐Roman, Xavier Sastre, Marc‐Henri Stern, Feixiong Cheng, Sabina Signoretti, Andrew Berchuck, Darell D. Bigner, Eric Lipp, Jeffrey R. Marks, Shannon Jones McCall, Roger E. McLendon, Angeles Alvarez Secord, Alexis Sharp, Madhusmita Behera, Daniel J. Brat, Amy Chen, Keith A. Delman, Seth Daniel Force, Fadlo Raja Khuri, Kelly R. Magliocca, Shishir Kumar Maithel, Jeffrey J. Olson, Taofeek Kunle Owonikoko, Alan Pickens, Suresh Ramalingam, Dong Moon Shin, Gabriel Sica, Erwin G. Van Meir, Hongzheng Zhang, Wil Eijckenboom, Ad Gillis, Esther Korpershoek, Leendert H. J. Looijenga, Wolter Oosterhuis, Hans Stoop, Kim E. van Kessel, Ellen C. Zwarthoff, Chiara Calatozzolo, Lucia Cuppini, Stefania Cuzzubbo, Francesco DiMeco, Gaetano Finocchiaro, Luca Mattei, Alessandro Perin, Bianca Pollo, Chu Chen, J. C. Houck, Pawadee Lohavanichbutr, Arndt Hartmann, Robert Stoehr, Robert Stoehr, Helge W. Taubert, Sven Wach, Bernd Wullich, Witold Kycler, Dawid Murawa, Maciej Wiznerowicz, Ki Young Chung, William Jeffrey Edenfield, Julie Martin, Eric Baudin, Glenn J. Bubley, Raphael Bueno, Assunta De Rienzo, William G. Richards, Steven N. Kalkanis, Tom Mikkelsen, Houtan Noushmehr, Lisa M. Scarpace, Nicolas M Girard, Marta Aymerich, Elı́as Campo, Eva Giné, Armando López Guillermo, Nguyen Van Bang, Phan Thi Hanh, Bùi Đức Phú, Yufang Tang, Howard Colman, Kimberley Jane Evason, Peter Remsen Dottino, John A. Martignetti, Hani Gabra, Hartmut H. Juhl, Teniola Akeredolu, Serghei Stepa, Dave S.�B. Hoon, Keunsoo Ahn, Koo Jeong Kang, Felix Beuschlein, Anne Breggia, Michael Birrer, Debra Bell, Mitesh J. Borad, Alan Haruo Bryce, Erik P. Castle, Vishal Suresh Chandan, John C. Cheville, John Alton Copland, Michael B. Farnell, Thomas James Flotte, Nasra H. Giama, Thai Huu Ho, Michael L. Kendrick, Jean‐Pierre Kocher, Karla J. Kopp, Catherine D. Moser, David M. Nagorney, Daniel R. O’Brien, Brian Patrick O’Neill, Tushar C. Patel, Gloria Petersen, Florencia G. Que, Michael Rivera, Lewis Rowland Roberts, Robert C. Smallridge, Thomas C. Smyrk, Melissa Stanton, Robert Houston Thompson, Michael S Torbenson, Ju Dong Yang, Lizhi Zhang, Fadi Brimo, Jaffer A. Ajani, Ana Maria Angulo Gonzalez, Carmen Behrens, Jolanta E. Bondaruk, Russell Broaddus, Bogdan A. Czerniak, Bita Esmaeli, Junya Fujimoto, Jeffrey Gershenwald, Charles Chuanhai Guo, Alexander J. Lazar, Christopher J. Logothetis, Funda Meric‐Bernstam, César A. Moran, Lois Michelle Ramondetta, David C. Rice, Anil K. Sood, Pheroze Tamboli, Timothy Thompson, Patricia Troncoso, Anne S. Tsao, Ignacio Wistuba, Candace Carter, Lauren Elaine Haydu, Peter Hersey, Valerie Jakrot, Hojabr Kakavand, Richard F. Kefford, Kenneth Maan Liong Lee, Georgina Venetia Long, Graham J. Mann, Michael C. J. Quinn, Robyn P.M. Saw, Richard A. Scolyer, Kerwin Frank Shannon, Andrew John Spillane, onathan Stretch, Maria Synott, John Russell Thompson, James S. Wilmott, Hikmat A Al‐Ahmadie, Timothy An-thy Chan, Ronald A. Ghossein, Anuradha Gopalan, Douglas A. Levine, Victor E. Reuter, Samuel Singer, Bhuvanesh Singh, Nguyen Viet Tien, Thomas B. Broudy, Cyrus Mirsaidi, Praveen P. Nair, Paul Drwiega, Judy Miller, Jennifer A. Smith, Howard A. Zaren, Joong‐Won Park, Nguyễn Phi Hùng, Electron Kebebew, William Marston Linehan, Adam R. Metwalli, Karel Pacák, Peter A. Pinto, MARK H. SCHIFFMAN, Laura S. Schmidt, Cathy D. Vocke, Nicolas Wentzensen, Robert Worrell, Hannah Yang, Marc D. Moncrieff, Chandra M. V. Goparaju, Jonathan Melamed, Harvey Ira Pass, Natalia Botnariuc, Irina Caraman, Mircea Cernat, Inga Chemencedji, Adrian Clipca, Serghei Doruc, Ghenadie Gorincioi, Sergiu Mura, Maria Pirtac, Irina Stancul, Diana Tcaciuc, Monique Albert, Iakovina Alexopoulou, Angel Arnaout, John A Bartlett, Jay Engel, Sébastien Gilbert, Jeremy R. Parfitt, Harman S. Sekhon, GEORGE V. THOMAS, Doris M. Rassl, Robert Campbell Rintoul, Carlo Bruno Bifulco, Raina Tamakawa, Walter John Urba, Nicholas K. Hayward, Henri Timmers, Anna Antenucci, Francesco Facciolo, Gian Luca Grazi, Mirella Marino, Roberta Merola, Ronald R. de Krijger, Anne‐Paule Gimenez‐Roqueplo, Alain Piché, Simone Chevalier, Ginette McKercher, Kıvanç Birsoy, Gene H. Barnett, Cathy J. Brewer, Carol F. Farver, Theresa Naska, Nathan A. Pennell, Daniel Raymond, Cathy Schilero, Kathy N. Smolenski, Felicia Williams, Quaid Morris, Jeffrey Allen Borgia, Michael J. Liptay, Mark D. Pool, Christopher William Seder, Kerstin Junker, Larsson Omberg, Mikhail Dinkin, George M. Manikhas, Domenico Alvaro, Maria Consiglia Bragazzi, Vincenzo Cardinale, Guido Carpino, Eugenio Gaudio, David W. Chesla, Sandra L. Cottingham, Michael Dubina, Fedor Vladimirovich Moiseenko, Renumathy Dhanasekaran, Karl‐Friedrich Becker, Klaus‐Peter Janssen, Julia Slotta‐Huspenina, Mohamed H. Abdel‐Rahman, Dina Aziz, Sue Ellen Bell, Colleen M. Cebulla, Amy Davis, Rebecca Duell, James Bradley Elder, Joe Hilty, Bahavna Kumar, James C. Lang, Norman L. Lehman, Randy Mandt, Phuong Nguyen, Robert Pilarski, Karan Rai, Lynn R. Schoenfield, Kelly Senecal, Paul E. Wakely, Paul Hansen, Ronald Michael Lechan, James Powers, Arthur S. Tischler, William E. Grizzle, Katherine C. Sexton, Alison Kastl, Joel Henderson, Sima P. Porten, Jens Waldmann, Martin Faßnacht, Sylvia L. Asa, Dirk Schadendorf, Marta Couce, Markus Graefen, Hartwig Huland, Guido Sauter, Thorsten Schlomm, Ronald Simon, Pierre Tennstedt, Oluwole Olabode, Mark A. Nelson, Oliver F. Bathe, Peter R. Carroll, June M. Chan, Philip John DiSaia, Pat Glenn, Robin Kate Kelley, Charles N. Landen, Joanna Phillips, Michael Prados, Jeffry Simko, Karen Smith‐McCune, Scott L. Vandenberg, Kevin King Roggin, Ashley Fehrenbach, Ady Kendler, Suzanne Sifri, Ruth Steele, Antonio Jimeno, Francis A. Carey, Ian M. Forgie, Massimo Mannelli, Michael E. Carney, Brenda Hernandez, Benito Campos, Christel C. Herold‐Mende, Christin Jungk, Andreas Wilhelm Unterberg, Andreas von Deimling, Aaron Bossler, Joseph Galbraith, Laura Jacobus, Michael C. Knudson, Tina M. Knutson, Deqin Ma, Mohammed M. Milhem, Rita D. Sigmund, Andrew K. Godwin, Rashna Madan, Howard G. Rosenthal, Clement Adebamowo, Sally Nneoma Adebamowo, Alex Boussioutas, David G. Beer, Thomas J. Giordano, Anne‐Marie Mes‐Masson, Fred Saad, Therese J. Bocklage, Lisa Michelle Landrum, Robert S. Mannel, Kathleen Moore, Katherine Marie Moxley, Russel G. Postier, Joan L. Walker, Rosemary E. Zuna, Michael M. Feldman, Federico Valdivieso, Rajiv Dhir, James D. Luketich, Edna M. Mora Pinero, Mario Quintero-Aguilo, Carlos Gilberto Carlotti, José Sebastião dos Santos, Rafael Kemp, Ajith Kumar Sankarankuty, Daniela Pretti da Cunha Tirapelli, James W.F. Catto, Kathy J. Agnew, Elizabeth M. Swisher, Jenette Creaney, Bruce W. S. Robinson, Carl Simon Shelley, Eryn M. Godwin, Sara Kendall, Cassaundra Shipman, Carol Rossier Bradford, Thomas E. Carey, Andrea Haddad, Jeffey Moyer, Lisa A. Peterson, Mark E. Prince, Laura S. Rozek, Gregory T. Wolf, Rayleen Bowman, Kwun Meng Fong, Ian A. Yang, Robert J. Korst, W. Kimryn Rathmell, J. Leigh Fantacone-Campbell, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, John F. DiPersio, Bettina F. Drake, Ramaswamy Govindan, Sharon E. Heath, Timothy James Ley, Brian Andrew Van Tine, Peter Westervelt, Mark Andrew Rubin, Jung Il Lee, Natália D. Aredes, Armaz Mariamidze, Alexander J. Lazar, Jonathan Stuart Serody, Elizabeth G. Demicco, Mary Lenora Disis, Benjamin Garrett Vincent, Ilya Shmulevich · 发表于：Immunity · 年份：2019 · DOI：10.1016/j.immuni.2019.08.004 · 被引用次数：811 · 研究领域：Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses、Immune Cell Function and Interaction

(Immunity 48, 812–830.e1–e14; April 17, 2018) In the originally published version of this article, the authors neglected to include Younes Mokrab and Aaron M. Newman as co-authors and misspelled the names of authors Charles S. Rabkin and Ilya Shmulevich. The author names have been corrected here and online. In addition, the concluding sentence of the subsection “Immune Signature Compilation” in the Method Details in the original published article was deemed unclear because it did not specify differences among the gene set scoring methods. The concluding sentences now reads “Gene sets from Bindea et al., Senbabaoglu et al., and the MSigDB C7 collection were scored using single-sample gene set enrichment (ssGSEA) analysis (Barbie et al., 2009), as implemented in the GSVA R package (Hänzelmann et al., 2013). All other signatures were scored using methods found in the associated citations.” The Immune Landscape of CancerThorsson et al.ImmunityApril 5, 2018In BriefThorsson et al. present immunogenomics analyses of more than 10,000 tumors, identifying six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis. This work provides a resource for understanding tumor-immune interactions, with implications for identifying ways to advance research on immunotherapy. Full-Text PDF Open Access