Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis

作者：Youchun Hu, Adwoa Nyantakyiwaa Amoah, Han Zhang, Rong Fu, Yanfang Qiu, Yuan Cao, Yafei Sun, Huanan Chen, Yanhua Liu, Quanjun Lyu · 发表于：The Journal of Maternal-Fetal & Neonatal Medicine · 年份：2020 · DOI：10.1080/14767058.2020.1712714 · 被引用次数：53 · 研究领域：Pregnancy and Medication Impact、Nausea and vomiting management、Pharmacological Effects and Toxicity Studies

Introduction Nausea and vomiting (NV) affect up to 85% of pregnant women, which has multiple effects on pregnancy outcome. The truth etiology of nausea and vomiting in pregnancy (NVP) is still unknown. Considering the potential teratogenic effect in fetus due to chemical drugs, ginger can be used to treat nausea and vomiting during pregnancy. Reports have shown that ginger can reduce the severity of NV, however, these results are controversial. Therefore, this meta-analysis aims to explore the effect of ginger in the treatment of nausea and vomiting during pregnancy compared with placebo and vitamin B6.Methods The randomized control trials (RCTs) on the association with ginger and pregnancy-related nausea and vomiting were searched and identified in two databases Web of Science and PubMed (up to April 2019). Stata software was used to conduct meta-analysis. In addition, the source of heterogeneity explored by metaregression, sensitivity analysis, subgroup analyses, the publication bias were assessed by Egger’s tests and Funnel plot, p < .05 was considered to be significant.Results Thirteen studies involving 1174 subjects were included in this meta-analysis. The result demonstrated that ginger intervention has significant effect in improving general symptom of NVP [OR = 7.475, 95% CI = (4.133, 13.520), I2 = 30.1%], relieving severity of nausea [SMD = 0.821, 95% CI = (0.585, 1.056), I2 = 38.9%], but not significant in reducing vomiting [SMD = 0.549, 95% CI = (−0.268, 1.365), I2...