Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors

作者：Di Chen, Na Sun, Lei Hou, Rachel Kim, Jared E. Faith, M. M. Aslanyan, Yu Tao, Yi Zheng, Jianping Fu, Wanlu Liu, Manolis Kellis, Amander T. Clark · 发表于：Cell Reports · 年份：2019 · DOI：10.1016/j.celrep.2019.11.083 · 被引用次数：206 · 研究领域：Pluripotent Stem Cells Research、CRISPR and Genetic Engineering、Single-cell and spatial transcriptomics

progenitors upstream of PRDM1 to regulate the expression of SOX17. This serves to protect hPGCLCs from crossing the Weismann's barrier to adopt somatic cell fates and, therefore, is an essential mechanism for successfully initiating in vitro gametogenesis.