Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release

作者：Delan Huang, Jianhan Ren, Runze Li, Chenyu Guan, Zhicai Feng, Baicheng Bao, Weicai Wang, Chen Zhou · 发表于：Stem Cell Reviews and Reports · 年份：2019 · DOI：10.1007/s12015-019-09940-0 · 被引用次数：44 · 研究领域：dental development and anomalies、Cancer-related gene regulation、Bone and Dental Protein Studies

Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.