808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer

作者：Jiahe Hu, Jialan Shi, Yingqian Gao, Wei Yang, Ping Liu, Qinghao Liu, Fei He, Chunxu Wang, Tao Li, Rui Xie, Jiuxin Zhu, Piaoping Yang · 发表于：International Journal of Nanomedicine · 年份：2019 · DOI：10.2147/ijn.s221496 · 被引用次数：35 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Luminescence Properties of Advanced Materials

Background: It is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) is a novel technique to treat liver cancer, but its clinical application is obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer is a potential solution to the limitations of PDT for deep tumor tissue treatment. Purpose: We aimed to investigate 808 nm NIR light-excited [email protected] 2 -Ce6-GPC3 nanocomposites for PDT in liver cancer. Methods: In our study, 808 nm NIR light-excited upconversion nanoparticles (UCNPs) were simultaneously loaded with the photosensitizer chlorin e6 (Ce6) and the antibody glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma cells. The multitasking [email protected] 2 -Ce6-GPC3 nanoparticles under 808 nm laser irradiation with enhanced depth of penetration would enable the effective targeting of PDT. Results: We found that the [email protected] 2 -Ce6-GPC3 nanoparticles had good biocompatibility, low toxicity, excellent cell imaging in HepG2 cancer cells and high anti-tumor effect in vitro and in vivo. Conclusion: We believe that the utilization of 808 nm NIR excited [email protected] 2 -Ce6-GPC3 nanoparticles for PDT is a safe and potential therapeutic option for liver cancer. Keywords: liver cancer, photodynamic therapy, upconversion nanoparticles, 808 nm NIR, GPC3, targeted therapy