Thiamine ameliorates inflammation of the ruminal epithelium of Saanen goats suffering from subacute ruminal acidosis

作者：Hao Zhang, Along Peng, Fangfang Zhao, Lihuai Yu, M.Z. Wang, J. S. Osorio, Hongrong Wang · 发表于：Journal of Dairy Science · 年份：2019 · DOI：10.3168/jds.2019-16944 · 被引用次数：43 · 研究领域：Ruminant Nutrition and Digestive Physiology、Gout, Hyperuricemia, Uric Acid、Alcohol Consumption and Health Effects

percentage (27.57 vs. 34.07%) also decreased in response to thiamine. Compared with HC goats, THC goats had lower ruminal epithelium activity of the enzymes myeloperoxidase and matrix metalloproteinase (MMP) 2 and 9. In contrast to HC, THC had downregulated mRNA expression of nuclear factor-κB (NFKB), TLR4, IL1B, MMP2, and MMP9 in ruminal epithelium. Thiamine supplementation led to lower relative protein expression of IL-1β, NF-κB unit p65, and phosphorylated NF-κB unit p65 in ruminal epithelium. Taken together, these results suggest that thiamine supplementation mitigates HC-induced local inflammation and ruminal epithelial disruption.