Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

作者：Songjiao Li, Peipei Wang, Wenqi Feng, Yunhui Xiang, Kun Dou, Zhihong Liu · 发表于：Chemical Communications · 年份：2019 · DOI：10.1039/c9cc08267k · 被引用次数：174 · 研究领域：Molecular Sensors and Ion Detection、Sulfur Compounds in Biology、Lanthanide and Transition Metal Complexes

It has been speculated that both the intracellular viscosity and H2O2 level in Alzheimer's disease (AD) brains are higher than that in healthy brains, but direct evidence from living beings is scarce. Herein, we report a NIR emissive fluorescent probe with a large Stokes shift for the associated detection of mitochondrial viscosity and H2O2 in live rat brains with AD for the first time.