Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

作者：Phil H. Lee, Verneri Anttila, Hyejung Won, Yen‐Chen Anne Feng, Jacob L. Rosenthal, Zhaozhong Zhu, Elliot M. Tucker–Drob, Michel G. Nivard, Andrew David Grotzinger, Daniëlle Posthuma, Meg M.-J. Wang, Dongmei Yu, Eli A. Stahl, Raymond K. Walters, Richard Anney, Laramie E. Duncan, Tian Ge, Rolf Adolfsson, Tobias Banaschewski, Sintia Iole Belangero, Edwin H. Cook, Giovanni Coppola, Eske M. Derks, Pieter J. Hoekstra, Jaakko A. Kaprio, Anna Keski‐Rahkonen, George Kirov, Henry R. Kranzler, Jurjen Justin Luykx, Luís Augusto Rohde, Clement C.H. Zai, Esben Agerbo, Maria Jesús Arranz, Philip J. Asherson, Marie Bækvad‐Hansen, Gísli Baldursson, Mark A. Bellgrove, Richard A. Belliveau, Jan K. Buitelaar, Christie L. Burton, Jonas Bybjerg‐Grauholm, Miguel Casas, Felecia E. Cerrato, Kimberly Chambert, Claire Churchhouse, Bru Cormand, Jennifer Crosbie, Søren Dalsgaard, Ditte Demontis, Alysa E. Doyle, Ashley Dumont, Josephine Elia, Jakob Grove, Ólafur Ó. Guðmundsson, Jan Haavik, Hakon H. Hakonarson, Christine Søholm Hansen, Catharina Annette Hartman, Ziarih Hawi, Amaia Hervás, DAVID MICHAEL HOUGAARD, Daniel P. Howrigan, Hailiang Huang, Jonna Kuntsi, K. Langley, Klaus‐Peter Lesch, Patrick W. L. Leung, Sandra K. Loo, Joanna Martin, Alicia R. Martin, James J. McGough, Sarah Elizabeth Medland, Jennifer L. Moran, Ole N Mors, Preben Bo Mortensen, Robert D. Oades, Duncan S. Palmer, Carsten Bøcker Pedersen, Marianne G. Pedersen, Triinu Peters, Timothy Poterba, Jesper Buchhave Poulsen, Josep Antoni Ramos‐Quiroga, Andreas Reif, Marta Ribasés, Aribert Rothenberger, Paula Rovira, Cristina Sánchez‐Mora, F. Kyle Satterstrom, Russell James Schachar, María Soler Artigas, Stacy Steinberg, Hreinn Stefánsson, Patrick K. Turley, G. Bragi Walters, Thomas Mears Werge, Tetyana Zayats, Dan E. Arking, Francesco Bettella, Joseph D. Buxbaum, Jane Christensen, Ryan L. Collins, Hilary H Coon, Silvia De Rubeis, Richard Delorme, Dorothy E. Grice, Thomas Folkmann Hansen, Peter Holmans, Sigrun Hope, Christina M. Hultman, Lambertus Klei, Christine Ladd‐Acosta, Páll Magnússon, Terje Nærland, Mette Nyegaard, Dalila Pinto, Per Qvist, Karola Rehnström, Abraham Reichenberg, Jennifer G. Reichert, Kathryn Roeder, Guy Armand Rouleau, Evald Sæmundsen, Stephan Sanders, Sven Sandin, Beaté St Pourcain, Kāri Stefánsson, James S. Sutcliffe, Michael E. Talkowski, Lauren A. Weiss, Arthur Jeremy Willsey, Ingrid Agartz, Huda Akil, Diego Albani, Martin Alda, Thomas D. Als, Adebayo Anjorin, Lena Backlund, Nicholas Bass, Michael S. Bauer, Bernhard Theodor Baune, Frank Bellivier, Sarah E. Bergen, Wade H. Berrettini, Joanna M. Biernacka, Douglas Blackwood, Erlend Bøen, Monika Budde, William Edward Bunney, Margit Burmeister, William Byerley, Enda M. Byrne, Sven Cichon, Toni‐Kim Clarke, Jonathan R. I. Coleman, Nicholas Craddock, David Curtis, Piotr M. Czerski, Anders Martin Dale, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Torbjørn Elvsåshagen, Bruno Étain, Sascha B. Fischer, Andreas J. Forstner, Liz Forty, Josef Frank, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Héléna A. Gaspar, Elliot S. Gershon, Michael Gill, Fernando S. Goes, Scott D. Gordon, Katherine Gordon‐Smith, Melissa J. Green, Tiffany A. Greenwood, Maria Grigoroiu‐Serbânescu, Jose Guzman Parra, Joanna D. Hauser, Martin Hautzinger, Urs Heilbronner, Stefan Herms, Per Hoffmann, Dominic Holland, Stéphane Jamain, Ian Richard Jones, Lisa Anne Jones, Radhika Kandaswamy, John R. Kelsoe, James L. Kennedy, Oedegaard Ketil Joachim, Sarah Kittel‐Schneider, Manolis Kogevinas, Anna C. Koller, Catharina Lavebratt, Cathryn M. Lewis, Qingqin S. Li, Jolanta Lissowska, Loes M. Olde Loohuis, Susanne Lucae, Anna Maaser, Ulrik Fredrik Malt, Nicholas G. Martin, Lina Martinsson, Susan L. McElroy, Francis J. McMahon, Andrew McQuillin, Ingrid S. Melle, Andres Metspalu, Vincent Millischer, Philip Bowden Mitchell, Grant W. Montgomery, Gunnar Morken, Derek W. Morris, Bertram Müller‐Myhsok, Niamh Mullins, R Myers, Caroline M. Nievergelt, Merete Nordentoft, Annelie Nordin Adolfsson, Markus Maria Nöthen, Roel A. Ophoff, Michael J. Owen, Sara A. Paciga, Carlos N. Pato, Michele T. Pato, Roy H. Perlis, Amy L. Perry, James B. Potash, Céline Sonja Reinbold, Marcella Rietschel, Margarita Rivera, Mary Roberson, Martin Schalling, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Engilbert Sigurðsson, Olav Bjerkehagen Smeland, Eystein Stordal, Fabian Streit, Jana Strohmaier, Thorgeir Elís Thorgeirsson, Jens Treutlein, Gustavo Turecki, Arne E. Vaaler, Eduard Vieta, John B. Vincent, Yunpeng Wang, Stephanie H. Witt, Peter P. Zandi, Roger A.H. Adan, Lars S. Alfredsson, Tetsuya Ando, Harald N. Aschauer, Jessica H. Baker, Vladimír Bencko, Andrew W. Bergen, Andreas Birgegård, Vesna Boraska Perica, Harry Brandt, Roland Burghardt, Laura Carlberg, Matteo Cassina, Maurizio Clementi, Philippe Courtet, Steven F. Crawford, Scott J. Crow, James J. Crowley, Unna Nora Danner, Oliver S. P. Davis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Christian Dina, Elisa Docampo, Karin Maria Egberts, Stefan Ehrlich, Thomas Espeseth, Fernando Fernández‐Aranda, Manfred M. Fichter, Lenka Foretová, Monica Forzan, Giovanni Gambaro, Ina Giegling, Fragiskos K. Gonidakis, Philip A. P. M. Gorwood, Monica Gratacos Mayora, Yiran Guo, Katherine Ann Halmi, Konstantinos Hatzikotoulas, Johannes Hebebrand, Sietske G. Helder, Beate Herpertz‐Dahlmann, Wolfgang Herzog, Anke Hinney, Hartmut Imgart, Susana Jiménez‐Múrcia, Craig Johnson, Jennifer J. Jordan, Antonio Julià, Deborah Kaminská, Leila J. Karhunen, Andreas F. K. Karwautz, Martien J. Kas, Walter H. Kaye, Martin Alexander Kennedy, Youl‐Ri Kim, Lars Klareskog, Kelly L. Klump, Gun Peggy Knudsen, Mikael Landén, Stéphanie Le Hellard, Robert D. Levitan, Dong Li, Paul Lichtenstein, Mario Maj, Sara Marsal, Sara McDevitt, James Earl Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Melissa A. Munn‐Chernoff, Benedetta Nacmias, Marie Navratilova, Julie K. O’Toole, Leonid Padyukov, Jacques Pantel, Hana Papežová, Raquel Rabionet, Anu Raevuori, Nicolás Ramoz, Ted Reichborn‐Kjennerud, Valdo Ricca, Marion Roberts, Dan Rujescu, Filip Rybakowski, André Scherag, Ulrike Schmidt, Jochen Seitz, Lenka LS Slachtova, M Landt, Agnieszka Slopien, Sandro Sorbi, Lorraine Southam, Michael A. Strober, Alfonso Antonio Vincenzo Tortorella, Federica Tozzi, Janet Treasure, Konstantinos Tziouvas, Annemarie Elburg, Tracey D. Wade, Gudrun Wagner, Esther Walton, Hunna J. Watson, H-Erich Wichmann, D. Blake Woodside, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Mark J. Adams, Till F. M. Andlauer, Klaus Berger, Elisabeth B. Binder, Dorret I. Boomsma, Enrique Castelao, Lucía Colodro‐Conde, Neşe Direk, Anna R. Docherty, Enrico Domenici, Katharina Domschke, Erin C. Dunn, Jerome C. Foo, E.J.C. de. Geus, Hans Jörgen Grabe, Steven P. Hamilton, Carsten Horn, Jouke‐Jan Hottenga, David M. Howard, Marcus Ising, Stefan M. Kloiber, Douglas F. Levinson, Glyn Lewis, Patrik K. E. Magnusson, Hamdi Mbarek, Christel Maria Middeldorp, Sara Mostafavi, Dale R. Nyholt, Brenda W.J.H. Penninx, Roseann Elizabeth Peterson, Giorgio Pistis, David J. Porteous, Martin Preisig, Jorge Quiroz, Catherine Schaefer, Eva Christina Schulte, Jianxin Shi, Daniel J. Smıth, Pippa A. Thomson, Henning W. Tiemeier, Rudolf Uher, Sandra Van der Auwera, Myrna M. Weissman, Madeline Alexander, Martin Begemann, Elvira Bramon, Nancy G. Buccola, Murray J. Cairns, Dominique Campion, Vaughan J. Carr, Claude Robert Cloninger, David Cohen, David Andrew Collier, Aiden P. Corvin, Lynn E. DeLisi, Gary J Donohoe, Frank Dudbridge, Jubao Duan, Robert Freedman, Pablo V. Gejman, В. Е. Голимбет, Stephanie Godard, Hannelore Ehrenreich, Annette M. Hartmann, Frans A. Henskens, Masashi Ikeda, Nakao Iwata, Assen V Jablensky, Inge Joa, Erik Gunnar Jönsson, Brian J. Kelly, Jo Knight, Bettina Konte, Claudine Laurent‐Levinson, Jimmy Lee, Todd Lencz, Bernard Lerer, Carmel Maree Loughland, Anil K. Malhotra, Jacques Mallet, Colm McDonald, Marina Mitjans, Bryan J. Mowry, Kieran C. Murphy, Robin M. Murray, F. Anthony O’Neill, Sang-Yun Oh, Aarno V. Palotie, Christos Pantelis, Ann E. Pulver, Tracey L. Petryshen, Digby J. Quested, Brien P. Riley, Alan R. Sanders, Ulrich Schall, Sibylle G. Schwab, Rodney J. Scott, Pak Chung Sham, Jeremy M. Silverman, Kang Sim, Agnes A. Steixner, Paul A. Tooney, Jim van Os, Marquis P. Vawter, Dermot Walsh, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Brandon K. Wormley, Fuquan Zhang, Christos Androutsos, Paul D. Arnold, Cathy L. Barr, Csaba Barta, Katharina Bey, Oscar Joseph Bienvenu, Donald W. Black, Lawrence W. Brown, Cathy L. Budman, Danielle Cath, Keun‐Ah Cheon, Valentina Ciullo, Barbara J. Coffey, Daniele Cusi, Lea K. Davis, Damiaan A J P Denys, Christel Depienne, Andrea Dietrich, Valsamma Eapen, Peter Falkai, Thomas V. Fernandez, Blanca García-Delgar, DANIEL A. GELLER, Donald L. Gilbert, Marco A. Grados, Erica Greenberg, Edna Grünblatt, Julie Hagstrøm, Gregory L. Hanna, Andreas Hartmann, Tammy Hedderly, Gary A. Heiman, Isobel Heyman, Hyun Ju Hong, Alden Huang, Chaim Huyser, Laura Ibanez-Gomez, Ekaterina A. Khramtsova, Young Key Kim, Young-Shin Kim, Robert A. King, Yun‐Joo Koh, Anastasios C. Konstantinidis, Sodahm Kook, Samuel Kuperman, BENNETT L. LEVENTHAL, Christine Löchner, Andrea G. Ludolph, Marcos Madruga-Garrido, Irene A. Malaty, Athanasios Maras, James T. McCracken, Inge A. Meijer, Pablo Mir, Ástrid Morer, Kirsten Müller‐Vahl, Alexander Maximilian Münchau, Tara Murphy, Allan L. Naarden, Péter Nagy, Gerald Nestadt, Paul Sasha Nestadt, Humberto Nicolini, Erika L. Nurmi, Michael S. Okun, Peristera Paschou, Fabrizio Piras, Federica Piras, Christopher Pittenger, Kerstin Jessica Plessen, Margaret Anne Richter, Renata Rizzo, Mary May Robertson, Veit Roessner, Stephan Ruhrmann, JACK F. SAMUELS, Paul Sandor, Monika Schlögelhofer, Eun‐Young Shin, Harvey Singer, Dong‐Ho Song, Jungeun Song, Gianfranco Spalletta, Dan J. Stein, S. Evelyn Stewart, Eric A. Storch, Barbara E. Stranger, Manfred Stuhrmann, Zsanett Tárnok, Jay A. Tischfield, Jennifer Tübing, Frank E. Visscher, Nienke Vulink, Michael Wagner, Susanne Walitza, Sina Wanderer, Martin Woods, Yulia Worbe, Gwyneth C. Zai, Samuel H. Zinner, Patrick F. Sullivan, Barbara Franke, Mark J. Daly, Cynthia Marie Bulik, Cathryn M. Lewis, Andrew Mark McIntosh, Michael C. O’Donovan, Amanda B. Zheutlin, Ole A. Andreassen, Anders Dupont Børglum, Gerome D. Breen, Howard J. Edenberg, Ayman H. Fanous, Stephen V. Faraone, Joel E. Gelernter, Carol A. Mathews, Manuel Mattheisen, Karen S. Mitchell, Michael C. Neale, John I. Nürnberger, Stephan Ripke, Susan L. Santangelo, Jeremiah M. Scharf, Murray B. Stein, Laura M. Thornton, James Walters, Naomi R. Wray, Daniel H. Geschwind, Benjamin M. Neale, Kenneth S. Kendler, Jordan W. Smoller · 发表于：Cell · 年份：2019 · DOI：10.1016/j.cell.2019.11.020 · 被引用次数：1523 · 研究领域：Genetic Associations and Epidemiology、Obsessive-Compulsive Spectrum Disorders、Genomics and Rare Diseases