Effect of Transcranial Alternating Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial

作者：Hong-xing Wang, Li Wang, Wen-rui Zhang, Qing Xue, Peng Mao, Zhi-Chao Sun, Li-Ping Li, Kun Wang, Xiao-Tong Yang, Yu Jia, Qi-Lin Zhou, Zhe-Xue Xu, Ning Li, Kai Dong, Qian Zhang, Hai-qing Song, Shu-Qin Zhan, Bao-quan Min, Chun-Qiu Fan, Ai-Hong Zhou, Xiuhua Guo, Hai-Bin Li, Li-Rong Liang, Lu Yin, Tian-Mei Si, Jing Huang, Tian-yi Yan, Fiammetta Cosci, Atsushi Kamiya, Jie Lu, Yu‐Ping Wang · 发表于：Psychotherapy and Psychosomatics · 年份：2019 · DOI：10.1159/000504609 · 被引用次数：108 · 研究领域：Sleep and related disorders、Sleep and Wakefulness Research、Transcranial Magnetic Stimulation Studies

BACKGROUND: Not all adults with chronic insomnia respond to the recommended therapeutic options of cognitive behavioral therapy and approved hypnotic drugs. Transcranial alternating current stimulation (tACS) may offer a novel potential treatment modality for insomnia. OBJECTIVES: This study aimed to examine the efficacy and safety of tACS for treating adult patients with chronic insomnia. METHODS: Sixty-two participants with chronic primary insomnia received 20 daily 40-min, 77.5-Hz, 15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas in the laboratory on weekdays for 4 consecutive weeks, followed by a 4-week follow-up period. The primary outcome was response rate measured by the Pittsburgh Sleep Quality Index (PSQI) at week 8. Secondary outcomes were remission rate, insomnia severity, sleep onset latency (SOL), total sleep time (TST), sleep efficiency, sleep quality, daily disturbances, and adverse events at the end of the 4-week intervention and at the 4-week follow-up. RESULTS: Of 62 randomized patients, 60 completed the trial. During the 4-week intervention, 1 subject per group withdrew due to loss of interest and time restriction, respectively. Based on PSQI, at 4-week follow-up, the active group had a higher response rate compared to the sham group (53.4% [16/30] vs. 16.7% [5/30], p = 0.009), but remission rates were not different between groups. At the end of the 4-week intervention, the active group had higher response and remission ra...